Vinculin (VCL) is a 1135-residue protein from Gallus gallus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P12003.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 86.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 63% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion
Exhibits self-association properties. Interacts with APBB1IP, NRAP and TLN1. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin
Cell membrane, Cell junction, adherens junction, Cell junction, focal adhesion, Cytoplasm, cytoskeleton, Cell membrane, sarcolemma, Cell projection, podosome, Cytoplasm, perinuclear region
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1QKR | X-ray | 1.8 Å | A/B=947-1135 |
| 1ZVZ | X-ray | 1.8 Å | A=2-259 |
| 1T01 | X-ray | 2.06 Å | A=1-254 |
| 1ZW2 | X-ray | 2.1 Å | A=2-259 |
| 3ZDL | X-ray | 2.3 Å | A=1-259 |
| 4E17 | X-ray | 2.3 Å | A=1-259 |
| 1U6H | X-ray | 2.38 Å | A=1-259 |
| 4E18 | X-ray | 2.4 Å | A=1-259 |
| 1XWJ | X-ray | 2.6 Å | A=2-259 |
| 2GDC | X-ray | 2.74 Å | A=1-266 |
| 6FQ4 | X-ray | 2.89 Å | A=1-259 |
| 6NR7 | X-ray | 3.0 Å | A=1-1135 |
| 1ST6 | X-ray | 3.1 Å | A=1-1135 |
| 1ZW3 | X-ray | 3.3 Å | A=2-259 |
| 3JBI | EM | 8.5 Å | V=879-1130 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.