Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) is a 317-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P12318.
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The mean pLDDT of this model is 76.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens
Binds the Fc region of antigen-complexed IgG1, IgG2, IgG3 and IgG4 isotypes (PubMed:11711607, PubMed:28566370, PubMed:37421619). Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR. Interacts with HCK
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3RY4 | X-ray | 1.5 Å | A=37-206 |
| 8CHA | X-ray | 1.81 Å | A=1-209 |
| 1FCG | X-ray | 2.0 Å | A=34-207 |
| 9N5P | X-ray | 2.01 Å | C=37-209 |
| 3RY5 | X-ray | 2.3 Å | A=37-206 |
| 9MCX | X-ray | 2.38 Å | C=37-209 |
| 3D5O | X-ray | 2.8 Å | F=37-207 |
| 1H9V | X-ray | 3.0 Å | A=37-208 |
| 3RY6 | X-ray | 3.8 Å | C=40-206 |
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