CD59 glycoprotein (CD59) is a 128-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13987.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 79.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 51% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 25% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation (PubMed:11882685, PubMed:1698710, PubMed:2475111, PubMed:2475570, PubMed:2606909, PubMed:9053451). Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (PubMed:11882685, PubMed:1698710, PubMed:36797260)
Interacts with T-cell surface antigen CD2
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2J8B | X-ray | 1.15 Å | A=26-103 |
| 2UWR | X-ray | 1.34 Å | A=26-102 |
| 2UX2 | X-ray | 1.8 Å | A/B/C=26-102 |
| 2OFS | X-ray | 2.12 Å | A=26-99 |
| 5IMY | X-ray | 2.4 Å | C/D=26-102 |
| 8CN6 | X-ray | 2.43 Å | A/B/C/D/E/F=26-101 |
| 5IMT | X-ray | 2.7 Å | D=26-102 |
| 8B0F | EM | 3.0 Å | G=1-120 |
| 8B0G | EM | 3.3 Å | G=26-102 |
| 8B0H | EM | 3.3 Å | G=1-128 |
| 4BIK | X-ray | 3.49 Å | B/D=26-102 |
| 6ZD0 | EM | 4.6 Å | B/D/F=26-102 |
| 1CDQ | NMR | A=26-102 | |
| 1CDR | NMR | A=26-102 | |
| 1CDS | NMR | A=26-102 | |
| 1ERG | NMR | A=26-95 | |
| 1ERH | NMR | A=26-95 |
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