Serine/threonine-protein kinase B-raf (BRAF) is a 766-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P15056.
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The mean pLDDT of this model is 66.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 29% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 39% |
What pLDDT means and how to read it
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179)
Monomer (PubMed:19710016). Homodimer (PubMed:19710016, PubMed:36402789). Heterodimerizes with RAF1, and the heterodimer possesses a highly increased kinase activity compared to the respective homodimers or monomers (PubMed:19710016). Heterodimerization is mitogen-regulated and enhanced by 14-3-3 proteins. MAPK1/ERK2 activation can induce a negative feedback that promotes the dissociation of the…
Nucleus, Cytoplasm, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8VSO | X-ray | 1.5 Å | P=361-369 |
| 8JNB | X-ray | 1.62 Å | B=201-210 |
| 8C7X | X-ray | 1.65 Å | A/B=444-721 |
| 8C7Y | X-ray | 1.65 Å | A/B=444-721 |
| 9EW6 | X-ray | 1.65 Å | P=361-369 |
| 8JNA | X-ray | 1.7 Å | B=201-210 |
| 9BP8 | X-ray | 1.73 Å | A=445-723 |
| 5VYK | X-ray | 1.75 Å | A/C=36-110 |
| 9BFB | X-ray | 1.92 Å | A=445-723 |
| 7K0V | X-ray | 1.93 Å | A/B/C/D=444-723 |
| 5ITA | X-ray | 1.95 Å | A/B=448-723 |
| 3NY5 | X-ray | 1.99 Å | A/B/C/D=153-237 |
| 4XV9 | X-ray | 2.0 Å | A=442-705 |
| 6XFP | X-ray | 2.0 Å | A=442-721 |
| 6N0Q | X-ray | 2.04 Å | A/B=445-723 |
| 9AXX | X-ray | 2.07 Å | B/D=445-723 |
| 5VAM | X-ray | 2.1 Å | A/B=445-723 |
| 5VR3 | X-ray | 2.1 Å | A=36-114 |
| 6P3D | X-ray | 2.11 Å | A=448-721 |
| 5JSM | X-ray | 2.19 Å | A/B/C/D=448-723 |
Showing 20 of 131 experimental structures (best resolution first).
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