Prolactin receptor (PRLR) is a 622-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P16471.
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The mean pLDDT of this model is 61.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 29% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 46% |
What pLDDT means and how to read it
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling
Homodimer upon hormone binding. Interacts with SMARCA1. Interacts with GH1. Interacts with CSH. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent
Membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3N06 | X-ray | 2.0 Å | B=25-234 |
| 3NCE | X-ray | 2.0 Å | B=25-234 |
| 3MZG | X-ray | 2.1 Å | B=25-234 |
| 3N0P | X-ray | 2.1 Å | B=25-234 |
| 3NCB | X-ray | 2.1 Å | B=25-234 |
| 3D48 | X-ray | 2.5 Å | R=25-234 |
| 3NCC | X-ray | 2.5 Å | B=25-234 |
| 3NCF | X-ray | 2.8 Å | B=25-234 |
| 1BP3 | X-ray | 2.9 Å | B=25-235 |
| 4I18 | X-ray | 3.24 Å | C/R=25-235 |
| 2LFG | NMR | A=123-234 | |
| 2N7I | NMR | A=230-264 |
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