Negative elongation factor E (NELFE) is a 380-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P18615.
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The mean pLDDT of this model is 64.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 11% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 42% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391)
The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE (PubMed:10199401, PubMed:27282391). Interacts with NELFB (By similarity)
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8UHG | EM | 2.7 Å | X=1-380 |
| 8UI0 | EM | 2.7 Å | X=1-380 |
| 8JJ6 | X-ray | 2.72 Å | E/F=1-50 |
| 5OOB | X-ray | 2.79 Å | E/K/Z=360-380 |
| 8UHD | EM | 2.8 Å | X=1-380 |
| 6GML | EM | 3.2 Å | X=1-380 |
| 9J0O | EM | 3.3 Å | X=1-380 |
| 9J0P | EM | 3.3 Å | X=1-380 |
| 9J0N | EM | 3.4 Å | X=1-380 |
| 8UHA | EM | 3.5 Å | X=1-380 |
| 8W8E | EM | 3.9 Å | X=1-380 |
| 7YCX | EM | 4.18 Å | h=1-380 |
| 1X5P | NMR | A=254-337 | |
| 2BZ2 | NMR | A=244-343 | |
| 2JX2 | NMR | A=244-343 |
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