Troponin I, cardiac muscle (TNNI3) is a 210-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P19429.
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The mean pLDDT of this model is 78.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 42% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 34% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity
Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8DZV | X-ray | 1.2 Å | C=40-52 |
| 7SC2 | X-ray | 1.81 Å | A=139-164 |
| 4Y99 | X-ray | 2.0 Å | C=1-210 |
| 7SC3 | X-ray | 2.23 Å | A=139-164 |
| 1J1D | X-ray | 2.61 Å | C/F=31-163 |
| 8FMO | X-ray | 2.61 Å | C/F=32-166 |
| 8FMT | X-ray | 2.8 Å | C/F=32-166 |
| 8FMN | X-ray | 3.1 Å | C/F=32-166 |
| 8FMM | X-ray | 3.11 Å | C/F=32-166 |
| 8FMP | X-ray | 3.24 Å | C/F=32-166 |
| 8FMR | X-ray | 3.24 Å | C/F=32-166 |
| 8FMQ | X-ray | 3.25 Å | C/F=32-166 |
| 1J1E | X-ray | 3.3 Å | C/F=31-210 |
| 8FMS | X-ray | 3.44 Å | C/F=32-166 |
| 6KN8 | EM | 4.8 Å | U/b=41-166 |
| 7UTI | EM | 4.8 Å | V/a=1-210 |
| 6KN7 | EM | 6.6 Å | U/b=41-210 |
| 7UTL | EM | 6.6 Å | V/c=1-210 |
| 1LXF | NMR | I=148-164 | |
| 1MXL | NMR | I=148-164 |
Showing 20 of 39 experimental structures (best resolution first).
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