Nuclear factor NF-kappa-B p105 subunit (NFKB1) is a 968-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P19838.
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The mean pLDDT of this model is 73.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they…
Component of the NF-kappa-B p65-p50 complex (PubMed:1740106, PubMed:7830764). Homodimer; component of the NF-kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50 complex (PubMed:1423592). Component of the NF-kappa-B p50-c-Rel complex (PubMed:15102766, PubMed:8152812). Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3 (PubMed:10469655). Also interacts with…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8TQD | X-ray | 2.02 Å | A=40-245 |
| 7LFC | X-ray | 2.1 Å | B=355-368 |
| 7RG5 | X-ray | 2.15 Å | B=331-370 |
| 7LEQ | X-ray | 2.24 Å | B=355-368 |
| 7LET | X-ray | 2.4 Å | B=355-368 |
| 1SVC | X-ray | 2.6 Å | P=2-365 |
| 7RG4 | X-ray | 2.6 Å | B=331-370 |
| 1NFI | X-ray | 2.7 Å | B/D=248-354 |
| 2O61 | X-ray | 2.8 Å | B=40-352 |
| 7LF4 | X-ray | 2.85 Å | B/F=355-368 |
| 3GUT | X-ray | 3.59 Å | B/D/F/H=41-352 |
| 1MDI | NMR | B=55-67 | |
| 1MDJ | NMR | B=55-67 | |
| 1MDK | NMR | B=55-67 | |
| 2DBF | NMR | A=806-893 |
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