Ras-related protein Rab-6A (RAB6A) is a 208-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P20340.
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The mean pLDDT of this model is 85.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 64% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron…
Interacts (GTP-bound) with DYNLRB1; the interaction is direct (PubMed:18044744). Interacts with BICD1 (PubMed:12447383). Interacts with BICD2; the interaction is direct (PubMed:12447383, PubMed:20386726, PubMed:23664119, PubMed:25962623). Interacts (GTP-bound) with VPS13B (PubMed:25492866)
Golgi apparatus membrane, Cytoplasmic vesicle, secretory vesicle, acrosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1YZQ | X-ray | 1.78 Å | A=10-177 |
| 2GIL | X-ray | 1.82 Å | A/B/C/D=13-174 |
| 4DKX | X-ray | 1.9 Å | A/B=1-208 |
| 5LEF | X-ray | 2.09 Å | A/B=8-195 |
| 3BBP | X-ray | 3.0 Å | A/B/C=1-206 |
| 3CWZ | X-ray | 3.2 Å | A=8-195 |
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