DNA-directed RNA polymerase III subunit RPC2 (RET1) is a 1149-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P22276.
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The mean pLDDT of this model is 87.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 64% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity)
Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7Z0H | EM | 2.6 Å | B=1-1149 |
| 7Z1O | EM | 2.7 Å | B=1-1149 |
| 7Z31 | EM | 2.76 Å | B=1-1149 |
| 7Z1L | EM | 2.8 Å | B=1-1149 |
| 7Z30 | EM | 2.9 Å | B=1-1149 |
| 7Z2Z | EM | 3.07 Å | B=1-1149 |
| 8BWS | EM | 3.2 Å | B=1-1149 |
| 6TUT | EM | 3.25 Å | B=1-1149 |
| 6EU3 | EM | 3.3 Å | B=1-1149 |
| 6EU1 | EM | 3.4 Å | B=1-1149 |
| 6EU2 | EM | 3.4 Å | B=1-1149 |
| 7Z1M | EM | 3.4 Å | B=1-1149 |
| 6F40 | EM | 3.7 Å | B=1-1149 |
| 5FJ8 | EM | 3.9 Å | B=1-1149 |
| 7Z1N | EM | 3.9 Å | B=1-1149 |
| 6EU0 | EM | 4.0 Å | B=1-1149 |
| 6CNB | EM | 4.1 Å | B=1-1149 |
| 6CNC | EM | 4.1 Å | B=1-1149 |
| 6F44 | EM | 4.2 Å | B=1-1149 |
| 6F41 | EM | 4.3 Å | B=1-1149 |
Showing 20 of 25 experimental structures (best resolution first).
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