Interleukin-10 (IL10) is a 178-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P22301.
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The mean pLDDT of this model is 87.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 78% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte…
Homodimer (PubMed:11485736, PubMed:15837194). Interacts with IL10RA and IL10RB (PubMed:16982608)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2ILK | X-ray | 1.6 Å | A=19-178 |
| 1ILK | X-ray | 1.8 Å | A=28-178 |
| 1LK3 | X-ray | 1.91 Å | A/B=25-178 |
| 1INR | X-ray | 2.0 Å | A=19-178 |
| 2H24 | X-ray | 2.0 Å | A=19-178 |
| 8SVE | X-ray | 2.4 Å | L/M=19-178 |
| 1Y6K | X-ray | 2.52 Å | L=19-178 |
| 1J7V | X-ray | 2.9 Å | L=19-178 |
| 6X93 | EM | 3.5 Å | A/D=19-178 |
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