1ILK: Interleukin-10

Interleukin-10 crystal structure reveals the functional dimer with an unexpected topological similarity to interferon gamma. Determined by X-ray diffraction at 1.8 Å resolution. Released 10 Jul 1995.

Method: X-ray diffraction
Resolution: 1.8 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,374
Mol. weight: 17.8 kDa
Released: 10 Jul 1995

Explore 1ILK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1ILK contains 11 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 0 β-strands

Element	Residues	Length
α-helix	19-40	22
α-helix	50-57	8
α-helix	61-71	11
α-helix	72-76	5
α-helix	77-80	4
α-helix	85-87	3
α-helix	88-107	20
α-helix	113-115	3
α-helix	119-131	13
α-helix	133-141	9
α-helix	143-158	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interleukin-10	A	protein	151	Homo sapiens	P22301 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1ILK_1 INTERLEUKIN-10 (chains A)
NSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMI
QFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFN
KLQEKGIYKAMSEFDIFINYIEAYMTMKIRN

Primary citation

Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma. Zdanov, A., Schalk-Hihi, C., Gustchina, A. et al. Structure (1995) 3:591-601. DOI 10.1016/S0969-2126(01)00193-9 · PubMed

Other PDB entries of the same protein (UniProt P22301 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2ILK 1.6 Å, Crystal structure of human interleukin-10 at 1.6 Å resolution
1LK3 1.91 Å, Engineered human interleukin-10 monomer complexed to 9D7 FAB fragment
1INR 2.0 Å, Cytokine synthesis
2H24 2.0 Å, Crystal structure of human IL-10
8SVE 2.4 Å, Structure of Monomeric Interleukin-10 Grafted into and Antibody CDR
1Y6K 2.52 Å, Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain
1J7V 2.9 Å, Human il-10 / il-10R1 complex
6X93 3.5 Å, Interleukin-10 signaling complex with IL-10RA and IL-10RB

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