Small ribosomal subunit protein uS3 (RPS3) is a 243-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P23396.
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The mean pLDDT of this model is 91.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 82% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA…
Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with HNRPD (PubMed:24423872). Interacts with PRMT1; the interaction methylates RPS3 (PubMed:19460357). Interacts with SUMO1; the interaction sumoylates RPS3 (PubMed:21968017). Interacts with UBC9…
Cytoplasm, Nucleus, Nucleus, nucleolus, Mitochondrion inner membrane, Cytoplasm, cytoskeleton, spindle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8GLP | EM | 1.67 Å | SD=1-243 |
| 8QOI | EM | 1.9 Å | SD=1-243 |
| 9O3W | EM | 1.9 Å | SD=1-243 |
| 8YOO | EM | 2.0 Å | SD=1-243 |
| 9C3H | EM | 2.0 Å | SK=1-243 |
| 7R4X | EM | 2.15 Å | D=1-243 |
| 9I2D | EM | 2.19 Å | SD=1-243 |
| 9PBE | EM | 2.19 Å | SD=1-227 |
| 8YOP | EM | 2.2 Å | SD=1-243 |
| 9O3Y | EM | 2.2 Å | SD=1-243 |
| 8JDK | EM | 2.26 Å | 0=1-243 |
| 8G5Y | EM | 2.29 Å | SD=1-243 |
| 9S3D | EM | 2.32 Å | SD=1-243 |
| 9RPV | EM | 2.35 Å | RD/SD=1-243 |
| 9S3B | EM | 2.38 Å | SD=1-243 |
| 8K2C | EM | 2.4 Å | SD=1-243 |
| 8XSX | EM | 2.4 Å | SD=1-243 |
| 9SPF | EM | 2.4 Å | SD=1-243 |
| 9SPI | EM | 2.4 Å | SD=1-243 |
| 8JDL | EM | 2.42 Å | 0=1-243 |
Showing 20 of 176 experimental structures (best resolution first).
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