Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) is a 913-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P26045.
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The mean pLDDT of this model is 73.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 41% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 27% |
What pLDDT means and how to read it
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity
Cell membrane, Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4RI5 | X-ray | 1.26 Å | A/B=628-909 |
| 2B49 | X-ray | 1.54 Å | A=628-913 |
| 4RHG | X-ray | 1.58 Å | A=628-909 |
| 4RH5 | X-ray | 1.6 Å | A=628-909 |
| 4RH9 | X-ray | 1.6 Å | A=628-909 |
| 4RI4 | X-ray | 1.6 Å | A/B=628-909 |
| 8CQY | X-ray | 1.7 Å | A=489-597 |
| 4S0G | X-ray | 1.72 Å | A=628-909 |
| 4QUN | X-ray | 1.86 Å | A/B=628-909 |
| 6T36 | X-ray | 1.86 Å | A=1-913 |
| 8OEP | X-ray | 1.87 Å | A/C=489-597 |
| 6HKS | X-ray | 2.19 Å | A/B/C/D/E/F=489-597 |
| 4QUM | X-ray | 2.52 Å | A=628-909 |
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