Protein PML (PML) is a 882-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P29590.
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The mean pLDDT of this model is 70.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 36% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 33% |
What pLDDT means and how to read it
Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and…
Key component of PML bodies. PML bodies are formed by the interaction of PML homodimers (via SUMO-binding motif) with sumoylated PML, leading to the assembly of higher oligomers. Several types of PML bodies have been observed. PML bodies can form hollow spheres that can sequester target proteins inside. Interacts (via SUMO-binding motif) with sumoylated proteins. Interacts (via C-terminus) with…
Nucleus, Nucleus, nucleoplasm, Cytoplasm, Nucleus, PML body, Nucleus, nucleolus, Endoplasmic reticulum membrane, Early endosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6UYR | X-ray | 1.3 Å | B=547-574 |
| 6UYV | X-ray | 1.4 Å | B=547-574 |
| 6UYP | X-ray | 1.42 Å | B=547-574 |
| 4WJO | X-ray | 1.46 Å | B=547-573 |
| 4WJN | X-ray | 1.5 Å | B=547-573 |
| 6UYQ | X-ray | 1.5 Å | B=547-574 |
| 6UYS | X-ray | 1.59 Å | B/D=546-573 |
| 5YUF | X-ray | 1.6 Å | A/B/C/D=49-99 |
| 6UYO | X-ray | 1.64 Å | B/D=547-574 |
| 6UYT | X-ray | 1.66 Å | B=547-574 |
| 6UYU | X-ray | 1.66 Å | B/D=547-574 |
| 8DJH | X-ray | 1.77 Å | B=546-573 |
| 8DJI | X-ray | 1.97 Å | B=547-574 |
| 6IMQ | X-ray | 2.06 Å | A/B/C/D=120-168 |
| 8J2P | X-ray | 2.09 Å | A/E=183-236 |
| 8J25 | X-ray | 2.6 Å | A=183-236 |
| 8YTC | EM | 5.3 Å | A/B=46-256 |
| 1BOR | NMR | A=49-104 | |
| 2MVW | NMR | A/B=120-168 | |
| 2MWX | NMR | A=49-104 |
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