Cytokine receptor common subunit gamma (IL2RG) is a 369-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P31785.
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The mean pLDDT of this model is 75.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770)
The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 and probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation. Interacts with IL9 (By similarity)
Cell membrane, Cell surface
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9E2T | X-ray | 2.28 Å | C/F=55-254 |
| 2B5I | X-ray | 2.3 Å | C=56-254 |
| 5M5E | X-ray | 2.3 Å | C=23-262 |
| 4GS7 | X-ray | 2.35 Å | C=55-254 |
| 7S2R | X-ray | 2.49 Å | A=54-254 |
| 9JQT | EM | 2.7 Å | A=23-262 |
| 8ENT | X-ray | 2.83 Å | C/F/I=55-254 |
| 3BPL | X-ray | 2.93 Å | C=56-254 |
| 9KMC | EM | 2.97 Å | C=23-255 |
| 2ERJ | X-ray | 3.0 Å | C/G=23-255 |
| 6OEL | X-ray | 3.1 Å | C=61-249 |
| 3QB7 | X-ray | 3.24 Å | C/D=55-254 |
| 8EPA | EM | 3.4 Å | I=23-262 |
| 3QAZ | X-ray | 3.8 Å | C/F/I/L/O/R/U/X/a/d/g/j=56-254 |
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