Beta-arrestin-2 (ARRB2) is a 420-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P32120.
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The mean pLDDT of this model is 83.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes (PubMed:37209686, PubMed:38175886). During homologous desensitization, beta-arrestins bind to the GPCR-phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits…
Homooligomer; the self-association is mediated by InsP6-binding (Probable). Heterooligomer with ARRB1; the association is mediated by InsP6-binding. Interacts with ADRB2 and CHRM2. Interacts with PDE4A. Interacts with PDE4D. Interacts with MAPK10, MAPK1 and MAPK3. Interacts with DRD2. Interacts with FSHR. Interacts with CLTC. Interacts with HTR2C. Interacts with CRR5. Interacts with CXCR4.…
Cytoplasm, Nucleus, Cell membrane, Membrane, clathrin-coated pit, Cytoplasmic vesicle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5TV1 | X-ray | 2.4 Å | A=8-404 |
| 9KY2 | EM | 2.78 Å | A/F=1-420 |
| 8J8R | EM | 2.9 Å | A/B/C=1-420 |
| 3P2D | X-ray | 3.0 Å | A/B=1-404 |
| 8J8V | EM | 3.22 Å | A/F=1-420 |
| 8VJ9 | EM | 3.3 Å | A=1-392 |
| 8GO9 | EM | 3.35 Å | A/F=1-420 |
| 8TIL | EM | 3.8 Å | A=1-403 |
| 8I10 | EM | 3.96 Å | A/B/C=1-420 |
| 8TIN | EM | 4.0 Å | A=1-403 |
| 8GOC | EM | 4.18 Å | A/B/C=1-420 |
| 8I0Z | EM | 4.33 Å | A/B/C=1-420 |
| 8GOO | EM | 4.4 Å | A/B/C=1-420 |
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