Nuclear polyadenylated RNA-binding protein NAB2 (NAB2) is a 525-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P32505.
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The mean pLDDT of this model is 71.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 16% |
| 70 to 90 | Confident: backbone generally right | 43% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 26% |
What pLDDT means and how to read it
RNA-binding protein involved in RNA processing and transcription regulation (PubMed:11779864, PubMed:11927564, PubMed:17630287, PubMed:17636033, PubMed:26119729, PubMed:26220998, PubMed:39461343). Acts as a regulator of mRNA stability: binds the poly(A) tail of mRNAs and pre-mRNAs, preventing their degradation by the exosome (PubMed:17636033, PubMed:26119729). Involved in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Involved in mRNA poly(A) tail length control and nuclear export (PubMed:11779864, PubMed:11927564). Functions in surveillance and the packaging leading to generation of export-competent mRNPs…
Interacts with MLP1 (PubMed:18190927, PubMed:18682389). Interacts with PUB1 (PubMed:17636033)
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5L2L | X-ray | 1.55 Å | A/B/E/F=407-483 |
| 2V75 | X-ray | 1.8 Å | A=1-104 |
| 3LCN | X-ray | 2.0 Å | A/B=1-105 |
| 4JLQ | X-ray | 3.04 Å | B=205-242 |
| 2JPS | NMR | A=1-105 | |
| 2LHN | NMR | A=409-483 | |
| 3ZJ1 | NMR | A=253-333 | |
| 3ZJ2 | NMR | A=333-401 |
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