Interleukin-13 (IL13) is a 146-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P35225.
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The mean pLDDT of this model is 85.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:8096327, PubMed:8097324). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (PubMed:7903680, PubMed:8759755). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and down-regulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF…
Interacts with IL13RA2
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3L5X | X-ray | 1.9 Å | A=35-146 |
| 4I77 | X-ray | 1.9 Å | Z=35-146 |
| 5L6Y | X-ray | 1.99 Å | C=35-146 |
| 3L5W | X-ray | 2.0 Å | I/J=35-146 |
| 4PS4 | X-ray | 2.8 Å | A=35-146 |
| 3BPO | X-ray | 3.0 Å | A=34-146 |
| 5E4E | X-ray | 3.0 Å | A=34-146 |
| 3LB6 | X-ray | 3.05 Å | A/B=15-146 |
| 3G6D | X-ray | 3.2 Å | A=35-146 |
| 8BLQ | EM | 3.97 Å | D=38-146 |
| 1GA3 | NMR | A=35-146 | |
| 1IJZ | NMR | A=35-146 | |
| 1IK0 | NMR | A=35-146 |
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