1IJZ: Human IL-13

Solution Structure of Human IL-13. Determined by solution NMR. Released 1 May 2002.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 872
Mol. weight: 12.49 kDa
Released: 1 May 2002

Explore 1IJZ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1IJZ contains 7 α-helices and 2 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	2-5	4
α-helix	6-22	17
β-strand	33-35	3	1
α-helix	43-51	9
α-helix	58-60	3
α-helix	61-70	10
α-helix	87-88	2
β-strand	89-91	3	1
α-helix	92-109	18

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interleukin-13	A	protein	113	Homo sapiens	P35225 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1IJZ_1 INTERLEUKIN-13 (chains A)
MGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAI
EKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN

Primary citation

Solution structure of human IL-13 and implication for receptor binding. Moy, F.J., Diblasio, E., Wilhelm, J. et al. J Mol Biol (2001) 310:219-230. DOI 10.1006/jmbi.2001.4764 · PubMed

Other PDB entries of the same protein (UniProt P35225 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3L5X 1.9 Å, Crystal structure of the complex between IL-13 and H2L6 FAB
4I77 1.9 Å, Lebrikizumab Fab bound to IL-13
5L6Y 1.99 Å, il13 in complex with tralokinumab
3L5W 2.0 Å, Crystal structure of the complex between IL-13 and C836 FAB
4PS4 2.8 Å, Crystal structure of the complex between IL-13 and M1295 FAB
3BPO 3.0 Å, Crystal structure of the IL13-IL4R-IL13Ra ternary complex
5E4E 3.0 Å, Engineered Interleukin-13 bound to receptor
3LB6 3.05 Å, The structure of IL-13 in complex with IL-13Ralpha2
3G6D 3.2 Å, Crystal structure of the complex between CNTO607 Fab and IL-13
8BLQ 3.97 Å, Cryo-EM structure of the CODV-IL13-RefAb triple complex
1GA3 NMR structure of interleukin-13
1IK0 Solution Structure of Human IL-13

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