Metabotropic glutamate receptor 5 (GRM5) is a 1212-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P41594.
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The mean pLDDT of this model is 71.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 45% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 33% |
What pLDDT means and how to read it
G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity
The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and TAMALIN. Interacts with NCDN (By similarity). Isoform 2 interacts with NECAB2 (PubMed:19694902). Interacts with CAMK2A (PubMed:28130356)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6FFI | X-ray | 2.2 Å | A=569-678, A=680-836 |
| 9HC0 | X-ray | 2.33 Å | A=569-678, A=680-836 |
| 3LMK | X-ray | 2.44 Å | A/B=18-505 |
| 7P2L | X-ray | 2.54 Å | A=569-678, A=680-836 |
| 4OO9 | X-ray | 2.6 Å | A=569-836 |
| 5CGD | X-ray | 2.6 Å | A=569-836 |
| 6FFH | X-ray | 2.65 Å | A=569-678, A=680-836 |
| 8TAO | EM | 2.9 Å | A/B=20-876 |
| 9HC3 | X-ray | 2.9 Å | A=569-678, A=680-836 |
| 8T8M | EM | 3.0 Å | A/B=20-876 |
| 8X0G | EM | 3.0 Å | A/B=21-856 |
| 5CGC | X-ray | 3.1 Å | A=569-836 |
| 8X0B | EM | 3.1 Å | A/B=21-856 |
| 8X0C | EM | 3.2 Å | A/B=21-856 |
| 6N4Y | X-ray | 3.26 Å | A/B/C/D=21-571 |
| 8T7H | EM | 3.3 Å | A/B=20-876 |
| 8X0F | EM | 3.3 Å | A/B=21-856 |
| 8X0E | EM | 3.4 Å | A/B=21-856 |
| 8T6J | EM | 3.5 Å | A/B=20-876 |
| 8X0D | EM | 3.5 Å | A/B=21-856 |
Showing 20 of 27 experimental structures (best resolution first).
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