Ribosomal protein S6 kinase alpha-3 (RPS6KA3) is a 740-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P51812.
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The mean pLDDT of this model is 76.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 35% |
| 70 to 90 | Confident: backbone generally right | 38% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes…
Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity). Interacts with NFATC4, ETV1/ER81 and FGFR1
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4NW6 | X-ray | 1.74 Å | A=39-359 |
| 8EQ5 | X-ray | 1.8 Å | A=46-346 |
| 4NW5 | X-ray | 1.94 Å | A=39-359 |
| 5D9L | X-ray | 2.15 Å | A=39-359 |
| 8R58 | X-ray | 2.31 Å | A=39-351 |
| 4NUS | X-ray | 2.39 Å | A=39-359 |
| 4D9T | X-ray | 2.4 Å | A=399-740 |
| 4D9U | X-ray | 2.4 Å | A=399-740 |
| 5D9K | X-ray | 2.55 Å | A/B=39-366 |
| 4JG6 | X-ray | 2.6 Å | A=399-740 |
| 8XEY | X-ray | 2.65 Å | A=400-740 |
| 7OPO | X-ray | 2.75 Å | A/C/E/G/I/K=39-351 |
| 4JG7 | X-ray | 3.0 Å | A=399-740 |
| 4JG8 | X-ray | 3.1 Å | A=399-740 |
| 8XFY | X-ray | 3.2 Å | A/B/C/D/E/F/G/H/I/J=40-359 |
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