Gasdermin-D (GSDMD) is a 484-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P57764.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 77.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 43% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27281216). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:26375259, PubMed:27281216, PubMed:39673710, PubMed:40118151)
Homooligomer; homooligomeric ring-shaped pore complex containing 27-28 subunits when inserted in the membrane (PubMed:33883744, PubMed:34289345, PubMed:38040708). Homooligomerization is promoted by the mTORC1 complex in macrophages (PubMed:34289345). In response to a canonical inflammasome stimulus, such as nigericin, recruited to NLRP3 inflammasone with similar kinetics to that of uncleaved…
Cytoplasm, cytosol, Inflammasome, Cell membrane, Secreted, Mitochondrion membrane, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9E0V | X-ray | 1.64 Å | A=276-484 |
| 7Z1X | X-ray | 1.86 Å | A/D=1-484 |
| 5NH1 | X-ray | 2.04 Å | A=278-484 |
| 5WQT | X-ray | 2.64 Å | A/B=276-484 |
| 6KN0 | X-ray | 2.79 Å | E/F=283-480 |
| 6AO4 | X-ray | 2.9 Å | A=277-484 |
| 6N9O | X-ray | 3.5 Å | A/B/C/D=1-484 |
| 6KMZ | X-ray | 3.61 Å | E=287-480, H=286-480 |
| 6VFE | EM | 3.9 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d=1-241 |
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