Envelope small membrane protein (E) is a 76-residue protein from Severe acute respiratory syndrome coronavirus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P59637.
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The mean pLDDT of this model is 71.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 41% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction
Homopentamer (PubMed:22819936). Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex (PubMed:19322648). Interacts with Nucleoprotein (PubMed:24766657). Interacts with the accessory proteins 3a and 7a. Interacts (via C-terminus) with human PALS1 (via PDZ domain); this inhibits the interaction between…
Host endoplasmic reticulum-Golgi intermediate compartment, Host Golgi apparatus membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7NTJ | X-ray | 1.74 Å | C/G=69-76 |
| 2MM4 | NMR | A=8-65 | |
| 5X29 | NMR | A/B/C/D/E=8-65 | |
| 5XER | NMR | A=55-63 | |
| 5XES | NMR | A=55-63 |
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