Interleukin-2 (IL2) is a 153-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P60568.
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The mean pLDDT of this model is 84.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 58% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 19% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance (PubMed:6438535). Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG) (PubMed:16293754, PubMed:16477002). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3 (PubMed:7973659). In turn, JAK1 and JAK3 phosphorylate the receptor to form a…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8SOZ | X-ray | 1.64 Å | A=20-153 |
| 8SOW | X-ray | 1.71 Å | A=20-153 |
| 7M2G | X-ray | 1.79 Å | A=21-153 |
| 4NEJ | X-ray | 1.92 Å | A=24-153 |
| 4NEM | X-ray | 1.93 Å | A=24-153 |
| 1M48 | X-ray | 1.95 Å | A/B=21-153 |
| 5LQB | X-ray | 1.95 Å | A=22-153 |
| 1M47 | X-ray | 1.99 Å | A=21-153 |
| 1M49 | X-ray | 2.0 Å | A/B=21-153 |
| 1M4B | X-ray | 2.15 Å | A=21-153 |
| 1M4A | X-ray | 2.18 Å | A=21-153 |
| 1NBP | X-ray | 2.2 Å | A=21-153 |
| 7RA9 | X-ray | 2.2 Å | A=21-153 |
| 2B5I | X-ray | 2.3 Å | A=21-153 |
| 5M5E | X-ray | 2.3 Å | D=8-153 |
| 1M4C | X-ray | 2.4 Å | A/B=21-153 |
| 7DR4 | X-ray | 2.49 Å | G/I/J/K=21-153 |
| 3INK | X-ray | 2.5 Å | C/D=21-153 |
| 1PW6 | X-ray | 2.6 Å | A/B=21-153 |
| 7YZJ | X-ray | 2.6 Å | E=84-92 |
Showing 20 of 37 experimental structures (best resolution first).
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