P62266: Small ribosomal subunit protein uS12 (RPS23)

Small ribosomal subunit protein uS12 (RPS23) is a 143-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62266.

Gene: RPS23
Organism: Homo sapiens
Length: 143 residues
Mean pLDDT: 94.9
Model: AF-P62266-F1 v6
Model created: 1 Aug 2025
PDB structures: 181

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Model confidence (pLDDT)

The mean pLDDT of this model is 94.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT band	Meaning	Share of residues
Above 90	Very high: backbone and side chains are usually accurate	94%
70 to 90	Confident: backbone generally right	6%
50 to 70	Low: treat with caution	1%
Below 50	Very low: often disordered regions	0%

What pLDDT means and how to read it

Function

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:28257692). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399, PubMed:25901680, PubMed:25957688). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399, PubMed:25901680, PubMed:25957688). The nascent…

Subunit structure

Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797)

Subcellular location

Cytoplasm, cytosol, Cytoplasm, Rough endoplasmic reticulum, Nucleus, nucleolus

Disease associations

Brachycephaly, trichomegaly, and developmental delay (BTDD)

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB ID	Method	Resolution	Chains and residues
8QOI	EM	1.9 Å	SX=1-143
9O3W	EM	1.9 Å	SX=1-143
8YOO	EM	2.0 Å	SX=1-143
9C3H	EM	2.0 Å	SX=1-143
7R4X	EM	2.15 Å	X=1-143
9I2D	EM	2.19 Å	SX=1-143
9PBE	EM	2.19 Å	SX=2-142
8YOP	EM	2.2 Å	SX=1-143
9O3Y	EM	2.2 Å	SX=1-143
8JDK	EM	2.26 Å	AJ=1-143
9S3D	EM	2.32 Å	SX=1-143
9RPV	EM	2.35 Å	RX/SX=1-143
9S3B	EM	2.38 Å	SX=1-143
8K2C	EM	2.4 Å	SX=1-143
8XSX	EM	2.4 Å	SX=1-143
8JDL	EM	2.42 Å	AJ=1-143
9S3C	EM	2.42 Å	SX=1-143
9QLO	EM	2.47 Å	SX=1-143
9P8B	EM	2.48 Å	SX=2-142
7XNY	EM	2.5 Å	SX=1-143

Showing 20 of 181 experimental structures (best resolution first).

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