Major outer membrane lipoprotein Lpp (lpp) is a 78-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P69776.
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The mean pLDDT of this model is 85.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 28% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
An outer membrane lipoprotein that controls the distance between the inner and outer membranes; adding residues to Lpp increases the width of the periplasm (PubMed:29257832). The only protein known to be covalently linked to the peptidoglycan network (PGN) (PubMed:3013869, PubMed:4245367, PubMed:4261992). Also non-covalently binds the PGN (PubMed:3013869). The link between the cell outer membrane and PGN contributes to the maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane (PubMed:3013869, PubMed:4245367, PubMed:4261992, PubMed:4565677). The most abundant cellular protein in terms of copy…
Homotrimer (PubMed:10843861, PubMed:3013869). Interacts with OmpA (PubMed:3013869). Has been isolated from outer membrane preparations as an approximately 87 kDa complex, suggesting it also forms larger complexes (PubMed:16079137). Seems to interact with TolB, Pal and TonB (PubMed:9701827). In pull-down experiments interacts with CedA (PubMed:28818726)
Cell outer membrane, Secreted, cell wall
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1JCD | X-ray | 1.3 Å | A/B/C=22-73 |
| 2GUV | X-ray | 1.4 Å | A/B/C/D/E=22-77 |
| 1T8Z | X-ray | 1.45 Å | A/B/C/D/E=22-74 |
| 1KFN | X-ray | 1.65 Å | A=22-77 |
| 1JCC | X-ray | 1.7 Å | A/B/C=22-77 |
| 2GUS | X-ray | 1.75 Å | A=22-77 |
| 1EQ7 | X-ray | 1.9 Å | A=22-77 |
| 1KFM | X-ray | 2.0 Å | A=22-77 |
| 9RLC | EM | 2.8 Å | L=21-77 |
| 9RLD | EM | 3.0 Å | L=21-77 |
| 7ARJ | EM | 3.2 Å | V=21-30 |
| 7ARL | EM | 3.2 Å | V=21-30 |
| 7ARH | EM | 3.3 Å | V=21-30 |
| 9GRC | EM | 3.5 Å | V=21-30 |
| 7ARM | EM | 3.6 Å | V=21-30 |
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