DNA repair protein crb2 (crb2) is a 778-residue protein from Schizosaccharomyces pombe (strain 972 / ATCC 24843). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P87074.
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The mean pLDDT of this model is 63.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 49% |
What pLDDT means and how to read it
Essential for cell cycle arrest at the G1 and G2 stages following DNA damage by X-, and UV-irradiation, or inactivation of DNA ligase. Plays a role in the response to DNA damage (PubMed:9153313, PubMed:9407031). Interaction with rad4 via its phosphorylation sites in the N-terminus couples the DNA checkpoint apparatus to chromatin via interaction of its C-terminal BRCT domains with epigenetic modifications on histones H4 and H2A, respectively, in the G1/S phase of the cell cycle, and facilitates recruitment of the checkpoint kinase chk1 (PubMed:15550243, PubMed:16778077, PubMed:18826944, PubMed:20679485, PubMed:22792081)
Homodimer. Dimerization is mediated via the BRCT domain (PubMed:16778077, PubMed:18676809). Interacts (via BRCT domain) with rad3 (PubMed:14739927). Interacts with rad4 (via BRCT1,2 domains) (PubMed:9407031, PubMed:14739927); a single rad4 molecule interacts simultaneously with both Thr-187 phosphorylation sites in a crb2 dimer (PubMed:24074952). Interacts (via Tudor domain) with histone…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4BU0 | X-ray | 1.5 Å | B/C=180-193 |
| 4BU1 | X-ray | 2.1 Å | C/D=229-241 |
| 2VXB | X-ray | 2.3 Å | A/B=538-778 |
| 2FHD | X-ray | 2.4 Å | A/B/C=358-507 |
| 2VXC | X-ray | 3.1 Å | A/B=537-778 |
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