Interleukin-6 receptor subunit beta (Il6st) is a 917-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q00560.
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The mean pLDDT of this model is 73.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Functions as a shared signal-transducing subunit not only for IL6 but also for other cytokine receptor complexes, including IL6, LIF, OSM, CNTF, IL11, CTF1, BSF3, MT-RNR2/humanin, CLCF1 and the heterodimeric complex CRLF1-CLCF1 (PubMed:1602143). Engages site 2 of CNTF, CLCF1, LIF, and IL-6, and site 3 of IL27 and IL6. Initiates signal transmission through three mechanisms (By similarity). Binding of cytokines, such as IL6 or IL11 to the alpha-chains of their specific cell surface receptor triggers homodimerization of IL6ST/gp130 (PubMed:10661409, PubMed:1602143). In contrast, binding of other IL-6 family cytokines can result in the formation of a IL6ST/gp130 heterodimer with another…
Homodimer in the IL6 complex receptor. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; associates with the complex IL6:IL6R but does not interact with IL6 (By similarity). Forms heterodimers composed of LIFR and IL6ST (type I OSM receptor) which are activated by LIF and OSM (By similarity). Also forms heterodimers composed of OSMR and IL6ST (type II receptor) which are…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2HMH | X-ray | 2.0 Å | B=753-763 |
| 8QY4 | EM | 3.06 Å | C/F=1-917 |
| 6C5X | X-ray | 3.1 Å | G=754-763 |
| 8QY5 | EM | 3.1 Å | A/D=1-917 |
| 8QY6 | EM | 3.16 Å | A/D=1-917 |
| 8V2C | EM | 3.46 Å | B=23-617 |
| 8V2B | EM | 3.67 Å | B=23-617 |
| 4GL9 | X-ray | 3.9 Å | I/J/K/L=750-764 |
| 7Z0L | EM | 4.0 Å | A=28-319 |
| 2BBU | NMR | B=750-764 |
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