Friend leukemia integration 1 transcription factor (FLI1) is a 452-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q01543.
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The mean pLDDT of this model is 63.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 49% |
What pLDDT means and how to read it
Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'
Can form homodimers or heterodimers with ETV6/TEL1
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9CP6 | X-ray | 1.66 Å | A=259-371 |
| 9MX9 | X-ray | 2.55 Å | A/D=259-399 |
| 9MXA | X-ray | 2.59 Å | A/D=259-399 |
| 5E8G | X-ray | 2.7 Å | A/B/C/D=276-399 |
| 5JVT | X-ray | 3.1 Å | A/D/G=276-375 |
| 9MX8 | X-ray | 3.15 Å | A/C/D=259-375 |
| 9MWY | X-ray | 3.28 Å | A/C/D/L=259-399 |
| 5E8I | X-ray | 3.45 Å | A/D/G/J=276-399 |
| 6VG2 | X-ray | 3.9 Å | A/D=276-375 |
| 6VGD | X-ray | 4.2 Å | A=276-375 |
| 6VG8 | X-ray | 4.31 Å | A=276-375 |
| 1FLI | NMR | A=276-373 | |
| 1X66 | NMR | A=114-198 | |
| 2YTU | NMR | A=100-220 |
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