ATP-dependent RNA helicase SUB2 (SUB2) is a 446-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q07478.
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The mean pLDDT of this model is 86.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 76% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
ATP-binding RNA helicase component of the TREX complex involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity. Associates with THO1, which facilitates RNA binding of SUB2 and likely plays a role in mRNA export (PubMed:37578863)
Component of the TREX complex composed of at least SUB2, TEX1, YRA1 and the four THO complex components: HPR1, MFT1, THO2 and THP1. Interacts with HPR1, YRA1, and YRA2. SUB2 may mediate the interaction between the THO complex and YRA1. Associates with growing mRNP complexes during transcription. This association requires the presence of HPR1. Also interacts with SAC3. Interacts with THO1 in the…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8U8C | X-ray | 2.4 Å | D=1-55 |
| 5SUP | X-ray | 2.6 Å | A/B/C=61-446 |
| 8U8D | EM | 3.04 Å | D=1-446 |
| 8U8E | EM | 3.33 Å | D=1-446 |
| 7APX | EM | 3.4 Å | F=48-446 |
| 7V2Y | EM | 3.4 Å | F=1-446 |
| 7LUV | EM | 3.7 Å | M=1-446 |
| 7AQO | EM | 4.5 Å | F/L=51-446 |
| 5SUQ | X-ray | 6.0 Å | A/C=1-446 |
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