Protein phosphatase 3 catalytic subunit alpha (PPP3CA) is a 521-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q08209.
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The mean pLDDT of this model is 85.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591, PubMed:30254215). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:22343722, PubMed:23468591, PubMed:27974827). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion…
Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B) (PubMed:12218175, PubMed:12357034, PubMed:17498738, PubMed:22343722, PubMed:23468591, PubMed:27974827, PubMed:8524402). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two…
Cytoplasm, Cell membrane, Cell membrane, sarcolemma, Cytoplasm, myofibril, sarcomere, Z line, Cell projection, dendritic spine
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2W73 | X-ray | 1.45 Å | K/L/M/O=395-411 |
| 4F0Z | X-ray | 1.7 Å | A=1-370 |
| 6UUQ | X-ray | 1.85 Å | A=26-339 |
| 2R28 | X-ray | 1.86 Å | C/D=389-413 |
| 6NUC | X-ray | 1.9 Å | A=1-370 |
| 6NUF | X-ray | 1.9 Å | A=1-370 |
| 4Q5U | X-ray | 1.95 Å | C=391-414 |
| 3LL8 | X-ray | 2.0 Å | A/C=14-370 |
| 9NXE | X-ray | 2.09 Å | A=1-370 |
| 1AUI | X-ray | 2.1 Å | A=1-521 |
| 9NXN | X-ray | 2.1 Å | A=1-370 |
| 2P6B | X-ray | 2.3 Å | A/C=1-380 |
| 6NUU | X-ray | 2.3 Å | A=1-370 |
| 5SVE | X-ray | 2.6 Å | A=1-370 |
| 1M63 | X-ray | 2.8 Å | A/E=1-372 |
| 1MF8 | X-ray | 3.1 Å | A=20-392 |
| 9NXF | X-ray | 3.13 Å | A/D=1-370 |
| 5C1V | X-ray | 3.35 Å | A/B=2-346 |
| 9B9G | EM | 3.5 Å | I/K=2-391 |
| 2JOG | NMR | A=21-347 |
Showing 20 of 21 experimental structures (best resolution first).
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