Metabotropic glutamate receptor 1 (GRM1) is a 1194-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13255.
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The mean pLDDT of this model is 70.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 45% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 33% |
What pLDDT means and how to read it
G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, PubMed:28886343, PubMed:7476890). May function in the light response in the retina (By similarity). Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell,…
Homodimer; disulfide-linked (PubMed:24603153). The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with TAMALIN (By similarity). Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with SIAH1 (By similarity)
Cell membrane, Postsynaptic cell membrane, Cell projection, dendrite
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3KS9 | X-ray | 1.9 Å | A/B=28-518 |
| 4OR2 | X-ray | 2.8 Å | A/B=581-860 |
| 7DGE | EM | 3.65 Å | A/B=31-863 |
| 7DGD | EM | 3.96 Å | A/B=31-863 |
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