Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) is a 499-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13557.
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The mean pLDDT of this model is 83.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'.…
CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (PubMed:14722083). Interacts with RRAD and CACNB2 (By similarity)
Cell membrane, sarcolemma, Sarcoplasmic reticulum membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3GP2 | X-ray | 1.46 Å | B=294-311 |
| 7ZRQ | X-ray | 1.68 Å | B=294-315 |
| 2WEL | X-ray | 1.9 Å | A=10-335 |
| 5VLO | X-ray | 2.05 Å | A/B=3-301 |
| 6AYW | X-ray | 2.05 Å | A/B=3-301 |
| 2VN9 | X-ray | 2.3 Å | A/B=10-309 |
| 9BLH | X-ray | 2.35 Å | A/B=10-309 |
| 7ZRP | X-ray | 2.65 Å | B/D=294-315 |
| 2W2C | X-ray | 2.7 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N=334-475 |
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