Crystal structure of SU6656-bound calcium/calmodulin-dependent protein kinase II delta in complex with calmodulin. Determined by X-ray diffraction at 1.9 Å resolution. Released 14 Apr 2009.
Explore 2WEL in 3D Show helices and sheets RCSB PDB PDBe
2WEL contains 26 α-helices and 17 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 0-13 | 4 | |
| β-strand | 14-23 | 10 | 1 |
| β-strand | 26-33 | 8 | 1 |
| β-strand | 39-46 | 8 | 1 |
| α-helix | 47-49 | 3 | |
| α-helix | 52-67 | 16 | |
| β-strand | 73 | 1 | 2 |
| β-strand | 76-82 | 7 | 1 |
| β-strand | 85-90 | 6 | 1 |
| β-strand | 97 | 1 | 2 |
| α-helix | 98-105 | 8 | |
| α-helix | 110-129 | 20 | |
| β-strand | 132-133 | 2 | 3 |
| α-helix | 139-141 | 3 | |
| β-strand | 142-144 | 3 | 2 |
| α-helix | 151-152 | 2 | |
| β-strand | 153-155 | 3 | 2 |
| α-helix | 158-160 | 3 | |
| β-strand | 162-163 | 2 | 3 |
| β-strand | 170 | 1 | 4 |
| α-helix | 178-180 | 3 | |
| α-helix | 183-186 | 4 | |
| β-strand | 191 | 1 | 4 |
| α-helix | 194-209 | 16 | |
| α-helix | 219-228 | 10 | |
| α-helix | 243-252 | 10 | |
| α-helix | 261-262 | 2 | |
| α-helix | 263-266 | 4 | |
| α-helix | 270-273 | 4 | |
| α-helix | 291-294 | 4 | |
| α-helix | 296-315 | 20 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 7-20 | 14 | |
| β-strand | 28 | 1 | 5 |
| α-helix | 30-39 | 10 | |
| α-helix | 46-56 | 11 | |
| β-strand | 64 | 1 | 5 |
| α-helix | 66-73 | 8 | |
| α-helix | 79-93 | 15 | |
| β-strand | 100-101 | 2 | 6 |
| α-helix | 103-112 | 10 | |
| α-helix | 119-129 | 11 | |
| β-strand | 137-138 | 2 | 6 |
| α-helix | 139-145 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Calcium/calmodulin-dependent protein kinase type II delta chain | A | protein | 327 | HOMO SAPIENS | Q13557 (AlphaFold model) |
| Calmodulin | D | protein | 150 | HOMO SAPIENS | P0DP23 (AlphaFold model) |
>2WEL_1 CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN (chains A) SMTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK DPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDL INKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTM LATRNFSAAKSLLKKPDGVKESTESSN
>2WEL_2 CALMODULIN (chains D) SMADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDAD GNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTD EEVDEMIREADIDGDGQVNYEEFVQMMTAK
| ID | Name | Formula | Copies |
|---|---|---|---|
| PO4 | Phosphate ion | O4 P | 2 |
| CA | Calcium ion | Ca | 4 |
| K88 | (3Z)-n,n-dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dih… | C19 H21 N3 O3 S | 1 |
Water and common crystallization additives (EDO) are not listed.
Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation. Rellos, P., Pike, A.C.W., Niesen, F.H. et al. PLoS Biol (2010) 8:426. DOI 10.1371/JOURNAL.PBIO.1000426 · PubMed
Other PDB entries of the same protein (UniProt Q13557 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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