Next to BRCA1 gene 1 protein (NBR1) is a 966-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q14596.
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The mean pLDDT of this model is 58.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 51% |
What pLDDT means and how to read it
Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133, PubMed:38169523). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body…
Homooligomer and heterooligomer. Interacts with TRIM55 (By similarity). Interacts with titin/TTN (By similarity). Interacts with RNF29, USP8, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2 (PubMed:19250911). Binds to ubiquitin and ubiquitinated proteins (PubMed:24692539). Interacts with SQSTM1 (PubMed:19250911). Interacts with TAX1BP1 (PubMed:33226137, PubMed:34471133). Interacts…
Cytoplasm, Cytoplasmic vesicle, autophagosome, Lysosome, Cytoplasm, myofibril, sarcomere, M line
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2BKF | X-ray | 1.56 Å | A=1-85 |
| 2G4S | X-ray | 2.15 Å | A=1-85 |
| 4OLE | X-ray | 2.52 Å | A/B/C/D=365-485 |
| 1WJ6 | NMR | A=1-85 | |
| 2CP8 | NMR | A=916-956 | |
| 2L8J | NMR | B=726-738 | |
| 2MGW | NMR | A=913-959 | |
| 2MJ5 | NMR | B=913-959 |
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