Indian hedgehog protein (IHH) is a 411-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q14623.
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The mean pLDDT of this model is 84.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Precursor of indian hedgehog, a morphogen that activates the smoothened signaling pathway, and which is essential for bone and cartilage development (By similarity). The C-terminal part of the precursor displays an autoproteolysis and a cholesterol transferase activity, resulting (1) in the cleavage of the full-length protein into two parts, indian hedgehog protein N-product and C-product and (2) covalent attachment of a cholesterol moiety to the C-terminus of the newly generated N-product (By similarity). Both autoproteolysis and a cholesterol transferase activities occur in the endoplasmic reticulum (By similarity). Following additional lipidation, N-product acts as a morphogen, while…
Multimer
Endoplasmic reticulum membrane, Golgi apparatus membrane, Secreted, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3K7I | X-ray | 1.44 Å | B=28-202 |
| 3K7G | X-ray | 1.5 Å | B=28-202 |
| 3K7H | X-ray | 1.5 Å | B=28-202 |
| 3N1F | X-ray | 1.6 Å | A/B=29-193 |
| 3N1M | X-ray | 1.69 Å | B=29-193 |
| 3K7J | X-ray | 1.9 Å | B=28-202 |
| 3N1O | X-ray | 2.55 Å | A/B/C=29-193 |
| 3N1P | X-ray | 2.7 Å | B=29-193 |
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