116 kDa U5 small nuclear ribonucleoprotein component (EFTUD2) is a 972-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15029.
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The mean pLDDT of this model is 89.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 76% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (PubMed:25092792, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (PubMed:16723661). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)
Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (PubMed:16723661, PubMed:26912367). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39 (PubMed:16723661, PubMed:26912367). Component of the…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8H6L | EM | 2.6 Å | 5C=1-972 |
| 8H6K | EM | 2.7 Å | 5C=1-972 |
| 8C6J | EM | 2.8 Å | C=1-972 |
| 6ID1 | EM | 2.86 Å | C=1-972 |
| 7DVQ | EM | 2.89 Å | C=1-972 |
| 6ID0 | EM | 2.9 Å | C=1-972 |
| 6QW6 | EM | 2.92 Å | 5C=104-956 |
| 6ICZ | EM | 3.0 Å | C=1-972 |
| 8I0R | EM | 3.0 Å | C=1-972 |
| 8I0T | EM | 3.0 Å | C=1-972 |
| 8I0V | EM | 3.0 Å | C=1-972 |
| 7QTT | EM | 3.1 Å | b=1-972 |
| 8Q7N | EM | 3.1 Å | C=1-972 |
| 8Q91 | EM | 3.1 Å | C=1-972 |
| 8QOZ | EM | 3.1 Å | C=1-972 |
| 8QPE | EM | 3.1 Å | C=1-972 |
| 8H6E | EM | 3.2 Å | 5C=1-972 |
| 8Q7Q | EM | 3.2 Å | C=1-972 |
| 8RC0 | EM | 3.2 Å | C=1-972 |
| 8H6J | EM | 3.25 Å | 5C=1-972 |
Showing 20 of 66 experimental structures (best resolution first).
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