8RC0: Human 20S U5 snRNP

Structure of the human 20S U5 snRNP. Determined by electron microscopy at 3.2 Å resolution. Released 27 Mar 2024.

Method: Electron microscopy
Resolution: 3.2 Å
Organism: Homo sapiens
Chains: 15
Atoms: 40,648
Mol. weight: 1040.57 kDa
Ligands: GTP
Released: 27 Mar 2024

Explore 8RC0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8RC0 contains 305 α-helices and 254 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 106 helices, 65 β-strands

Element	Residues	Length	Sheet
β-strand	60	1	3
α-helix	63-71	9
α-helix	86-92	7
α-helix	95-104	10
α-helix	106-108	3
β-strand	115-121	7	3
β-strand	127-129	3	3
β-strand	134-135	2	4
α-helix	137-155	19
α-helix	163-165	3
α-helix	174-177	4
α-helix	178-181	4
α-helix	187-189	3
α-helix	201-203	3
β-strand	220	1	5
β-strand	228-229	2	5
α-helix	232-241	10
α-helix	242-245	4
α-helix	260-268	9
α-helix	310-315	6
α-helix	329-331	3
α-helix	335-337	3
α-helix	357-358	2
α-helix	371-373	3
α-helix	399-403	5
α-helix	408	1
β-strand	415-416	2	5
β-strand	419-420	2	4
α-helix	421-423	3
α-helix	434-436	3
α-helix	441-459	19
α-helix	463-466	4
α-helix	472-478	7
β-strand	482-488	7	3
α-helix	489-509	21
β-strand	516-518	3	6
β-strand	524-526	3	6
α-helix	529-531	3
α-helix	534-536	3
α-helix	542-566	25
α-helix	571-583	13
α-helix	591-593	3
α-helix	598-616	19
α-helix	631-655	25
α-helix	681-696	16
α-helix	705-721	17
α-helix	733-763	31
α-helix	769-797	29
α-helix	803-819	17
α-helix	823-824	2
β-strand	825	1	7
α-helix	826-827	2
α-helix	835-849	15
α-helix	858-872	15
α-helix	874-886	13
β-strand	894-900	7	8
β-strand	905-910	6	8
α-helix	913-933	21
β-strand	940	1	9
α-helix	948-960	13
β-strand	973-979	7	9
β-strand	982	1	10
α-helix	990-1000	11
β-strand	1001	1	7
α-helix	1003-1012	10
β-strand	1016-1019	4	8
β-strand	1022-1025	4	8
α-helix	1037-1062	26
α-helix	1077-1080	4
β-strand	1085-1090	6	9
β-strand	1095-1101	7	9
α-helix	1103-1116	14
α-helix	1144-1160	17
β-strand	1167	1	10
α-helix	1170-1172	3
β-strand	1176-1178	3	9
β-strand	1185-1189	5	11
β-strand	1192-1198	7	11
β-strand	1213-1214	2	11
β-strand	1226-1229	4	11
β-strand	1232	1	11
α-helix	1234-1249	16
α-helix	1256-1273	18
α-helix	1275-1280	6
α-helix	1282-1303	22
α-helix	1314-1317	4
α-helix	1320-1322	3
α-helix	1327-1329	3
α-helix	1333	1
β-strand	1334	1	12
α-helix	1335-1336	2
α-helix	1337-1340	4
β-strand	1342-1346	5	13
β-strand	1349-1353	5	13
β-strand	1364	1	12
α-helix	1365-1367	3
α-helix	1368-1370	3
α-helix	1375-1399	25
α-helix	1409-1411	3
α-helix	1419-1423	5
α-helix	1427-1430	4
α-helix	1436-1441	6
α-helix	1443-1445	3
α-helix	1458-1461	4
α-helix	1468-1478	11
α-helix	1480-1486	7
α-helix	1490-1493	4
α-helix	1531-1537	7
α-helix	1539-1541	3
β-strand	1553-1554	2	2
α-helix	1555	1
β-strand	1561-1562	2	2
α-helix	1567-1575	9
α-helix	1581-1599	19
β-strand	1608-1611	4	14
α-helix	1618-1620	3
β-strand	1629-1640	12	14
β-strand	1652-1667	16	14
α-helix	1676-1687	12
β-strand	1700-1706	7	14
β-strand	1711-1714	4	14
α-helix	1722-1736	15
α-helix	1738-1751	14
α-helix	1768-1772	5
β-strand	1777-1781	5	15
β-strand	1787-1793	7	16
β-strand	1797-1803	7	16
β-strand	1805-1810	6	15
β-strand	1816-1822	7	15
α-helix	1824-1826	3
α-helix	1834-1851	18
β-strand	1860-1863	4	15
α-helix	1869-1875	7
β-strand	1883-1886	4	15
α-helix	1894-1898	5
α-helix	1900-1908	9
β-strand	1916-1918	3	15
α-helix	1923-1925	3
α-helix	1929-1945	17
α-helix	1947-1954	8
α-helix	1973-1994	22
α-helix	2004-2012	9
α-helix	2072-2080	9
α-helix	2083-2086	4
β-strand	2090-2092	3	17
β-strand	2097	1	17
β-strand	2103-2107	5	17
α-helix	2108-2116	9
β-strand	2125-2131	7	17
β-strand	2139-2147	9	17
β-strand	2150	1	18
β-strand	2151-2152	2	19
β-strand	2157-2158	2	19
α-helix	2163-2164	2
β-strand	2173-2181	9	17
α-helix	2190-2202	13
β-strand	2212-2217	6	17
β-strand	2223-2230	8	17
α-helix	2232-2240	9
α-helix	2253-2255	3
β-strand	2256-2258	3	17
β-strand	2260-2264	5	17
β-strand	2270-2272	3	17
β-strand	2273-2274	2	20
β-strand	2280	1	18
α-helix	2285-2287	3
β-strand	2296-2297	2	20
α-helix	2300-2303	4
α-helix	2307-2309	3
α-helix	2312-2315	4
α-helix	2317-2319	3

Chain B: 89 helices, 65 β-strands

Element	Residues	Length	Sheet
α-helix	59-61	3
α-helix	419-421	3
β-strand	436-438	3	30
β-strand	442-447	6	30
α-helix	448-456	9
β-strand	463	1	31
α-helix	469-472	4
β-strand	480	1	31
α-helix	483-487	5
α-helix	489-493	5
β-strand	499-502	4	32
α-helix	509-521	13
β-strand	537-541	5	32
α-helix	545-558	14
β-strand	566-568	3	32
α-helix	573-582	10
β-strand	585-588	4	32
α-helix	590-599	10
α-helix	603-605	3
β-strand	609-614	6	32
α-helix	617-621	5
α-helix	625-642	18
β-strand	647-652	6	32
α-helix	658-664	7
β-strand	673-675	3	32
α-helix	678-680	3
β-strand	685-692	8	30
α-helix	697-714	18
β-strand	721-724	4	30
α-helix	728-744	17
α-helix	756-768	13
α-helix	772-777	6
β-strand	782-785	4	30
α-helix	791-802	12
β-strand	808-811	4	30
α-helix	813-818	6
β-strand	823	1	33
β-strand	825-829	5	30
β-strand	832-835	4	34
β-strand	840-843	4	34
α-helix	844-845	2
α-helix	846-853	8
β-strand	856	1	33
β-strand	865-872	8	30
α-helix	876-882	7
α-helix	897-907	11
α-helix	913-921	9
α-helix	924-931	8
α-helix	940-944	5
α-helix	950-966	17
β-strand	970-972	3	35
β-strand	979-981	3	35
α-helix	983-991	9
α-helix	995-1004	10
α-helix	1011-1019	9
α-helix	1022-1024	3
α-helix	1031-1033	3
α-helix	1034-1041	8
α-helix	1055-1068	14
α-helix	1070-1072	3
α-helix	1075-1102	28
β-strand	1104	1	36
α-helix	1105-1120	16
α-helix	1128-1131	4
α-helix	1137-1145	9
α-helix	1150-1153	4
α-helix	1158-1164	7
α-helix	1171-1180	10
β-strand	1184-1191	8	37
β-strand	1197-1206	10	37
β-strand	1218-1226	9	38
β-strand	1232	1	36
β-strand	1233-1242	10	38
β-strand	1250-1257	8	37
β-strand	1265-1272	8	38
β-strand	1279-1285	7	38
α-helix	1291-1300	10
α-helix	1304-1307	4
β-strand	1308	1	39
α-helix	1309-1311	3
α-helix	1315-1318	4
β-strand	1327	1	39
α-helix	1330-1339	10
β-strand	1346-1349	4	40
α-helix	1356-1370	15
β-strand	1376-1379	4	40
α-helix	1383-1393	11
α-helix	1394-1398	5
β-strand	1405-1407	3	40
α-helix	1412-1421	10
β-strand	1424-1427	4	40
α-helix	1429-1436	8
α-helix	1443-1446	4
β-strand	1450-1454	5	40
α-helix	1456-1460	5
α-helix	1465-1478	14
β-strand	1486-1491	6	40
β-strand	1494	1	41
α-helix	1497-1503	7
β-strand	1511-1513	3	40
α-helix	1516-1518	3
β-strand	1523-1530	8	42
α-helix	1535-1541	7
α-helix	1543-1553	11
β-strand	1559-1563	5	42
α-helix	1566-1582	17
β-strand	1590	1	43
α-helix	1598-1601	4
α-helix	1607-1614	8
β-strand	1617-1619	3	42
α-helix	1626-1637	12
β-strand	1641	1	43
β-strand	1643-1647	5	42
α-helix	1648-1650	3
β-strand	1660-1664	5	42
β-strand	1667-1670	4	44
β-strand	1675-1678	4	44
α-helix	1679-1680	2
α-helix	1681-1689	9
β-strand	1700-1707	8	42
α-helix	1708-1710	3
α-helix	1711-1719	9
α-helix	1721	1
β-strand	1722	1	41
α-helix	1723	1
α-helix	1733-1741	9
β-strand	1747	1	45
α-helix	1748-1755	8
α-helix	1759-1764	6
α-helix	1768-1771	4
α-helix	1778-1798	21
β-strand	1802-1805	4	45
β-strand	1809-1812	4	45
α-helix	1814-1821	8
α-helix	1826-1835	10
α-helix	1842-1850	9
α-helix	1853-1855	3
α-helix	1865-1871	7
α-helix	1887-1900	14
α-helix	1906-1933	28
α-helix	1936-1951	16
α-helix	1968-1975	8
α-helix	1983-1986	4
α-helix	1990-1994	5
α-helix	2001-2013	13
β-strand	2017-2018	2	46
β-strand	2021-2023	3	47
β-strand	2034-2041	8	47
β-strand	2042-2043	2	46
β-strand	2064-2069	6	48
β-strand	2076-2082	7	48
β-strand	2088-2095	8	47
β-strand	2102-2110	9	48
β-strand	2118-2124	7	48

Chain C: 43 helices, 39 β-strands

Element	Residues	Length	Sheet
α-helix	116-122	7
β-strand	129-136	8	51
α-helix	143-152	10
α-helix	173-177	5
β-strand	184-191	8	51
β-strand	197-204	8	51
α-helix	209-211	3
α-helix	212-219	8
β-strand	224-228	5	51
α-helix	237-248	12
β-strand	252-257	6	51
α-helix	261	1
α-helix	262-266	5
α-helix	271-291	21
β-strand	307-311	5	51
α-helix	312-314	3
β-strand	316-318	3	51
α-helix	320-330	11
α-helix	336-339	4
α-helix	340-342	3
β-strand	348-350	3	52
β-strand	355-357	3	52
α-helix	365-366	2
β-strand	367	1	52
α-helix	368-369	2
α-helix	370-374	5
α-helix	375-386	12
α-helix	392-398	7
α-helix	412-424	13
α-helix	428-437	10
α-helix	445-452	8
β-strand	453	1	53
α-helix	461-464	4
β-strand	475-483	9	54
α-helix	484	1
β-strand	490-498	9	54
β-strand	500-502	3	55
β-strand	506-510	5	54
β-strand	523-526	4	54
β-strand	530-533	4	54
β-strand	538-541	4	54
β-strand	543-545	3	55
β-strand	549-552	4	54
β-strand	563-566	4	54
β-strand	577	1	53
α-helix	578-582	5
β-strand	588-594	7	56
α-helix	597-599	3
α-helix	600-613	14
β-strand	618-621	4	56
β-strand	627-631	5	56
α-helix	634-643	10
α-helix	644-648	5
β-strand	653-655	3	56
α-helix	656-658	3
β-strand	659-660	2	56
β-strand	663-666	4	57
α-helix	673	1
β-strand	674-677	4	58
β-strand	684-690	7	58
α-helix	691-693	3
α-helix	697-701	5
α-helix	711-722	12
α-helix	726-729	4
β-strand	732-735	4	58
β-strand	743-747	5	58
α-helix	756-759	4
α-helix	763-776	14
β-strand	783-784	2	57
β-strand	787-791	5	58
β-strand	795	1	58
α-helix	809-822	14
β-strand	825-839	15	57
α-helix	843-851	9
β-strand	856-862	7	57
β-strand	868-876	9	57
α-helix	878-880	3
α-helix	883-890	8
β-strand	896-906	11	57
α-helix	923-925	3
α-helix	926-928	3
α-helix	929-941	13

Chain D: 39 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	166-200	35
α-helix	244-254	11
α-helix	276-277	2
α-helix	278-280	3
α-helix	293-296	4
α-helix	298-300	3
α-helix	309-315	7
α-helix	319-327	9
α-helix	330-353	24
α-helix	367-376	10
β-strand	379-382	4	21
α-helix	386-389	4
α-helix	400-409	10
α-helix	416-425	10
β-strand	431-434	4	21
α-helix	441-454	14
α-helix	458-461	4
β-strand	471-474	4	21
α-helix	478-492	15
β-strand	499-502	4	21
α-helix	508-517	10
β-strand	521-524	4	21
α-helix	526-534	9
β-strand	545-549	5	21
α-helix	551-556	6
α-helix	560-568	9
α-helix	572-574	3
α-helix	576-577	2
α-helix	580-583	4
α-helix	585-593	9
α-helix	595-597	3
α-helix	599-600	2
β-strand	601-606	6	21
α-helix	611-620	10
α-helix	624	1
β-strand	625-629	5	21
α-helix	635-638	4
β-strand	640-645	6	22
α-helix	648-650	3
α-helix	651-660	10
β-strand	667-670	4	22
α-helix	674-686	13
β-strand	691-693	3	22
α-helix	704-712	9
β-strand	717-720	4	22
β-strand	735-738	4	22
α-helix	745-752	8
α-helix	753-755	3
β-strand	763-768	6	22
α-helix	770-775	6
α-helix	776-784	9
α-helix	793-796	4
α-helix	799-801	3

Chain E: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	96-113	18
α-helix	117-126	10
α-helix	138-149	12
α-helix	154-156	3

Chain F: 11 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	63-67	5
α-helix	68-71	4
β-strand	81	1	1
β-strand	86	1	1
β-strand	87	1	2
α-helix	93-98	6
α-helix	118-121	4
α-helix	151-153	3
α-helix	154-163	10
α-helix	165-166	2
α-helix	171-177	7
α-helix	196-212	17
α-helix	217-219	3
α-helix	222-232	11

Chain G: 0 helices, 29 β-strands

Element	Residues	Length	Sheet
β-strand	61-63	3	23
β-strand	71-74	4	24
β-strand	80-84	5	24
β-strand	89-94	6	24
β-strand	101-106	6	24
β-strand	112-117	6	25
β-strand	123-128	6	25
β-strand	133-137	5	25
β-strand	143-147	5	25
β-strand	154-159	6	26
β-strand	166-171	6	26
β-strand	175-180	6	26
β-strand	186-191	6	26
β-strand	196-201	6	27
β-strand	207-212	6	27
β-strand	216-221	6	27
β-strand	227-232	6	27
β-strand	238-243	6	28
β-strand	249-254	6	28
β-strand	258-263	6	28
β-strand	275-277	3	28
β-strand	291-293	3	29
β-strand	299-302	4	29
β-strand	309-313	5	29
β-strand	319-323	5	29
β-strand	330-335	6	23
β-strand	341-346	6	23
β-strand	350-352	3	23
β-strand	354-355	2	23

Chain h: 1 helix, 5 β-strands

Element	Residues	Length	Sheet
α-helix	7-10	4
β-strand	16-21	6	49
β-strand	26-34	9	49
β-strand	40-49	10	49
β-strand	63-72	10	49
β-strand	77-84	8	49

6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
CD2 antigen cytoplasmic tail-binding protein 2	F	protein	341	Homo sapiens	O95400 (AlphaFold model)
Pre-mRNA-processing-splicing factor 8	A	protein	2335	Homo sapiens	Q6P2Q9 (AlphaFold model)
U5 snRNA	5	RNA	117	Homo sapiens
Pre-mRNA-processing factor 6	E	protein	941	Homo sapiens	O94906 (AlphaFold model)
Probable ATP-dependent RNA helicase DDX23	D	protein	820	Homo sapiens	Q9BUQ8 (AlphaFold model)
U5 small nuclear ribonucleoprotein 40 kDa protein	G	protein	357	Homo sapiens	Q96DI7
U5 small nuclear ribonucleoprotein 200 kDa helicase	B	protein	2136	Homo sapiens	O75643
Small nuclear ribonucleoprotein Sm D1	i	protein	119	Homo sapiens	P62314
Small nuclear ribonucleoprotein Sm D3	k	protein	126	Homo sapiens	P62318
Small nuclear ribonucleoprotein E	l	protein	92	Homo sapiens	P62304
Small nuclear ribonucleoprotein F	m	protein	86	Homo sapiens	P62306
Small nuclear ribonucleoprotein G	n	protein	76	Homo sapiens	P62308

3 more molecules are not listed.

Sequence of entity 1 (F), FASTA

>8RC0_1 CD2 antigen cytoplasmic tail-binding protein 2 (chains F)
MPKRKVTFQGVGDEEDEDEIIVPKKKLVDPVAGSGGPGSRFKGKHSLDSDEEEDDDDGGS
SKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNRDAQIRDSWL
DNIDWVKIRERPPGQRQASDSEEEDSLGQTSMSAQALLEGLLELLLPRETVAGALRRLGA
RGGGKGRKGPGQPSSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCQTLGPH
NPTPPPSLDMFAEELAEEELETPTPTQRGEAESRGDGLVDVMWEYKWENTGDAELYGPFT
SAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT

Sequence of entity 2 (A), FASTA

>8RC0_2 Pre-mRNA-processing-splicing factor 8 (chains A)
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKED
MPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLY
HITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYR
LANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDIN
KIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRR
ALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATK
FFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMR
QIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQF
EGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCW
KANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLT
RLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLI
LALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMD
LYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGIN
NLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYK
DMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATE
AAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARM
RLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKC
RTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIV
NKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPK
ELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFI
DSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRT
DFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEG
LFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGI
FMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSY
KMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYA
RAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPAL
YVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTT
KPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQ
IIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLY
DDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVE
VQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLT
ATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKET
GYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLP
GQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTP
GSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWN
YNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA

Sequence of entity 3 (5), FASTA

>8RC0_3 U5 snRNA (chains 5)
AUACUCUGGUUUCUCUUCAGAUCGCAUAAAUCUUUCGCCUUUUACUAAAGAUUUCCGUGG
AGAGGAACAACUCUGAGUCUUAACCCAAUUUUUUGAGGCCUUGCUUUGGCAAGGCUA

Sequence of entity 4 (E), FASTA

>8RC0_4 Pre-mRNA-processing factor 6 (chains E)
MNKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQM
KKNQAADDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERR
EQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNKRQRNPRYEKLT
PVPDSFFAKHLQTGENHTSVDPRQTQFGGLNTPYPGGLNTPYPGGMTPGLMTPGTGELDM
RKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKS
VRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKA
VVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEEPEDAR
IMLSRAVECCPTSVELWLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNT
QMVEKIIDRAITSLRANGVEINREQWIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRK
HTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRA
VAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYER
ARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEE
QKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLW
LESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKCEHD
PHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKR
CESAEPRHGELWCAVSKDIANWQKKIGDILRLVAGRIKNTF

Sequence of entity 5 (D), FASTA

>8RC0_5 Probable ATP-dependent RNA helicase DDX23 (chains D)
MAGELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSR
SRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRK
DRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQE
VEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREE
KDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLG
RGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQK
KLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQ
AIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTREL
AQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVL
SRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYR
QTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILE
QGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVA
TDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELK
QAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA

Sequence of entity 6 (G), FASTA

>8RC0_6 U5 small nuclear ribonucleoprotein 40 kDa protein (chains G)
MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIM
LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD
GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD
IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG
LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI
AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ

Sequence of entity 7 (B), FASTA

>8RC0_7 U5 small nuclear ribonucleoprotein 200 kDa helicase (chains B)
MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTK
PQMQEERRAKRRKRDEDRHDINKMKGYTLLSEGIDEMVGIIYKPKTKETRETYEVLLSFI
QAALGDQPRDILCGAADEVLAVLKNEKLRDKERRKEIDLLLGQTDDTRYHVLVNLGKKIT
DYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYGEVREEASDDDMEGDEAVVRCTL
SANLVASGELMSSKKKDLHPRDIDAFWLQRQLSRFYDDAIVSQKKADEVLEILKTASDDR
ECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLLASAQSEAEKERIMGKMEADPELSKFL
YQLHETEKEDLIREERSRRERVRQSRMDTDLETMDLDQGGEALAPRQVLDLEDLVFTQGS
HFMANKRCQLPDGSFRRQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKT
LNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIY
IAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKG
GERTYTQLVRLIILDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYED
VATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQ
VLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPY
GFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGR
WTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDM
LNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTA
ALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSL
SSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMAD
MVYVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVV
KKIEKKNFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKV
ELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFE
PLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESL
YQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVYIT
PMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWK
QRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDV
AHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSPKKPVI
VFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYL
HEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVDYP
IYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEI
VTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSK
CISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPI
RHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAI
RLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHIKRCTDKGVE
SVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQ
LEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATG
AHNYTLYFMSDAYMGCDQEYKFSVDVKEAETDSDSD

Sequence of entity 8 (i), FASTA

>8RC0_8 Small nuclear ribonucleoprotein Sm D1 (chains i)
MKLVRFLMKLSHETVTIELKNGTQVHGTITGVDVSMNTHLKAVKMTLKNREPVQLETLSI
RGNNIRYFILPDSLPLDTLLVDVEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR

Sequence of entity 9 (k), FASTA

>8RC0_9 Small nuclear ribonucleoprotein Sm D3 (chains k)
MSIGVPIKVLHEAEGHIVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQ
VYIRGSKIRFLILPDMLKNAPMLKSMKNKNQGSGAGRGKAAILKAQVAARGRGRGMGRGN
IFQKRR

Sequence of entity 10 (l), FASTA

>8RC0_10 Small nuclear ribonucleoprotein E (chains l)
MAYRGQGQKVQKVMVQPINLIFRYLQNRSRIQVWLYEQVNMRIEGCIIGFDEYMNLVLDD
AEEIHSKTKSRKQLGRIMLKGDNITLLQSVSN

Sequence of entity 11 (m), FASTA

>8RC0_11 Small nuclear ribonucleoprotein F (chains m)
MSLPLNPKPFLNGLTGKPVMVKLKWGMEYKGYLVSVDGYMNMQLANTEEYIDGALSGHLG
EVLIRCNNVLYIRGVEEEEEDGEMRE

Sequence of entity 12 (n), FASTA

>8RC0_12 Small nuclear ribonucleoprotein G (chains n)
MSKAHPPELKKFMDKKLSLKLNGGRHVQGILRGFDPFMNLVIDECVEMATSGQQNNIGMV
VIRGNSIIMLEALERV

Ligands and cofactors

ID	Name	Formula	Copies
GTP	Guanosine-5'-triphosphate	C10 H16 N5 O14 P3	1

Primary citation

Structure of the human 20S U5 snRNP. Schneider, S., Brandina, I., Peter, D. et al. Nat Struct Mol Biol (2024) 31:752-756. DOI 10.1038/s41594-024-01250-5 · PubMed

Other PDB entries of the same protein (UniProt O95400 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1SYX 2.35 Å, The crystal structure of a binary U5 snRNP complex
4BWS 2.5 Å, Crystal structure of the heterotrimer of PQBP1, U5-15kD and U5-52kD.
8Q91 3.1 Å, Structure of the human 20S U5 snRNP core
8Q7Q 3.2 Å, Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 2)
8Q7V 3.8 Å, Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1)
8Q7W 3.9 Å, Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 3)
8Q7X 4.6 Å, Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 4)
1GYF Gyf domain from human CD2BP2 protein
1L2Z CD2BP2-GYF domain in complex with proline-rich CD2 tail segment peptide

Browse structure collections

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