8Q91: Human 20S U5 snRNP core
Structure of the human 20S U5 snRNP core. Determined by electron microscopy at 3.1 Å resolution. Released 27 Mar 2024.
- Method
- Electron microscopy
- Resolution
- 3.1 Å
- Organism
- Homo sapiens
- Chains
- 14
- Atoms
- 26,706
- Mol. weight
- 1001.21 kDa
- Ligands
- GTP
- Released
- 27 Mar 2024
Explore 8Q91 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8Q91 contains 163 α-helices and 127 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 81 helices, 43 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 60 | 1 | 5 |
| α-helix | 63-71 | 9 | |
| α-helix | 86-91 | 6 | |
| α-helix | 92-94 | 3 | |
| α-helix | 95-104 | 10 | |
| α-helix | 106-108 | 3 | |
| β-strand | 115-121 | 7 | 5 |
| β-strand | 127-129 | 3 | 5 |
| β-strand | 134-135 | 2 | 6 |
| α-helix | 137-155 | 19 | |
| α-helix | 163-165 | 3 | |
| α-helix | 174-177 | 4 | |
| α-helix | 178-181 | 4 | |
| α-helix | 185-189 | 5 | |
| α-helix | 201-203 | 3 | |
| β-strand | 220 | 1 | 7 |
| β-strand | 228-229 | 2 | 7 |
| α-helix | 232-241 | 10 | |
| α-helix | 242-245 | 4 | |
| α-helix | 260-268 | 9 | |
| β-strand | 294 | 1 | 8 |
| α-helix | 310-315 | 6 | |
| α-helix | 328-331 | 4 | |
| α-helix | 357-361 | 5 | |
| α-helix | 371-373 | 3 | |
| β-strand | 379 | 1 | 9 |
| α-helix | 399-403 | 5 | |
| α-helix | 408 | 1 | |
| β-strand | 415-416 | 2 | 7 |
| β-strand | 419-420 | 2 | 6 |
| α-helix | 421-423 | 3 | |
| α-helix | 434-436 | 3 | |
| α-helix | 441-459 | 19 | |
| α-helix | 463-466 | 4 | |
| α-helix | 472-478 | 7 | |
| β-strand | 482-488 | 7 | 5 |
| α-helix | 489-509 | 21 | |
| β-strand | 516-518 | 3 | 10 |
| β-strand | 524-526 | 3 | 10 |
| α-helix | 534-537 | 4 | |
| α-helix | 542-566 | 25 | |
| α-helix | 571-583 | 13 | |
| α-helix | 591-594 | 4 | |
| α-helix | 598-616 | 19 | |
| α-helix | 633-655 | 23 | |
| α-helix | 681-695 | 15 | |
| α-helix | 705-721 | 17 | |
| α-helix | 733-763 | 31 | |
| α-helix | 769-797 | 29 | |
| α-helix | 803-819 | 17 | |
| α-helix | 822-824 | 3 | |
| β-strand | 825 | 1 | 11 |
| α-helix | 826-829 | 4 | |
| α-helix | 835-849 | 15 | |
| α-helix | 858-872 | 15 | |
| α-helix | 874-887 | 14 | |
| β-strand | 894-901 | 8 | 12 |
| β-strand | 904-910 | 7 | 12 |
| α-helix | 913-933 | 21 | |
| β-strand | 940 | 1 | 13 |
| α-helix | 948-960 | 13 | |
| β-strand | 973-979 | 7 | 13 |
| β-strand | 982 | 1 | 14 |
| α-helix | 990-1000 | 11 | |
| β-strand | 1001 | 1 | 11 |
| α-helix | 1003-1012 | 10 | |
| β-strand | 1016-1019 | 4 | 12 |
| β-strand | 1022-1025 | 4 | 12 |
| α-helix | 1037-1053 | 17 | |
| α-helix | 1055-1062 | 8 | |
| α-helix | 1077-1080 | 4 | |
| β-strand | 1085-1090 | 6 | 13 |
| β-strand | 1095-1101 | 7 | 13 |
| α-helix | 1103-1116 | 14 | |
| α-helix | 1136-1138 | 3 | |
| β-strand | 1142 | 1 | 8 |
| α-helix | 1144-1160 | 17 | |
| β-strand | 1167 | 1 | 14 |
| α-helix | 1170-1172 | 3 | |
| β-strand | 1174-1178 | 5 | 13 |
| β-strand | 1185-1189 | 5 | 15 |
| β-strand | 1192-1198 | 7 | 15 |
| β-strand | 1213-1217 | 5 | 15 |
| β-strand | 1224-1232 | 9 | 15 |
| α-helix | 1234-1249 | 16 | |
| α-helix | 1256-1273 | 18 | |
| α-helix | 1275-1280 | 6 | |
| α-helix | 1282-1303 | 22 | |
| α-helix | 1314-1317 | 4 | |
| α-helix | 1320-1322 | 3 | |
| β-strand | 1332 | 1 | 16 |
| β-strand | 1334 | 1 | 17 |
| α-helix | 1337-1340 | 4 | |
| β-strand | 1342-1346 | 5 | 18 |
| β-strand | 1349-1353 | 5 | 18 |
| β-strand | 1364 | 1 | 17 |
| α-helix | 1365-1367 | 3 | |
| α-helix | 1368-1371 | 4 | |
| α-helix | 1375-1399 | 25 | |
| α-helix | 1409-1411 | 3 | |
| α-helix | 1419-1423 | 5 | |
| α-helix | 1427-1430 | 4 | |
| α-helix | 1436-1443 | 8 | |
| α-helix | 1458-1461 | 4 | |
| α-helix | 1468-1478 | 11 | |
| α-helix | 1480-1486 | 7 | |
| α-helix | 1490-1493 | 4 | |
| α-helix | 1531-1537 | 7 | |
| α-helix | 1539-1541 | 3 | |
| β-strand | 1553-1554 | 2 | 2 |
| α-helix | 1555 | 1 | |
| β-strand | 1561-1562 | 2 | 2 |
| α-helix | 1567-1576 | 10 | |
| α-helix | 1581-1599 | 19 | |
| α-helix | 1602-1604 | 3 | |
| β-strand | 1608-1611 | 4 | 19 |
| α-helix | 1618-1620 | 3 | |
| β-strand | 1629-1640 | 12 | 19 |
| β-strand | 1652-1667 | 16 | 19 |
| α-helix | 1676-1688 | 13 | |
| β-strand | 1700-1706 | 7 | 19 |
| β-strand | 1711-1714 | 4 | 19 |
| α-helix | 1722-1736 | 15 | |
| α-helix | 1738-1751 | 14 | |
Chain B: 3 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 39-40 | 2 | |
| β-strand | 41 | 1 | 16 |
| α-helix | 42 | 1 | |
| α-helix | 59-61 | 3 | |
Chain C: 43 helices, 38 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 116-122 | 7 | |
| α-helix | 126-128 | 3 | |
| β-strand | 129-136 | 8 | 20 |
| α-helix | 142-150 | 9 | |
| α-helix | 151-153 | 3 | |
| α-helix | 172-177 | 6 | |
| β-strand | 184-191 | 8 | 20 |
| β-strand | 197-204 | 8 | 20 |
| α-helix | 209-211 | 3 | |
| α-helix | 212-220 | 9 | |
| β-strand | 224-230 | 7 | 20 |
| α-helix | 237-248 | 12 | |
| β-strand | 252-258 | 7 | 20 |
| α-helix | 261 | 1 | |
| α-helix | 262-266 | 5 | |
| α-helix | 271-292 | 22 | |
| α-helix | 302-304 | 3 | |
| β-strand | 307-311 | 5 | 20 |
| α-helix | 312-314 | 3 | |
| β-strand | 316-318 | 3 | 20 |
| α-helix | 320-330 | 11 | |
| α-helix | 336-340 | 5 | |
| β-strand | 348-350 | 3 | 9 |
| β-strand | 355-357 | 3 | 9 |
| α-helix | 365-366 | 2 | |
| β-strand | 367 | 1 | 9 |
| α-helix | 368-369 | 2 | |
| α-helix | 370-374 | 5 | |
| α-helix | 375-386 | 12 | |
| α-helix | 392-399 | 8 | |
| α-helix | 405-408 | 4 | |
| α-helix | 412-424 | 13 | |
| α-helix | 428-436 | 9 | |
| α-helix | 441-452 | 12 | |
| β-strand | 453 | 1 | 21 |
| α-helix | 460-467 | 8 | |
| β-strand | 475-483 | 9 | 22 |
| β-strand | 490-498 | 9 | 22 |
| β-strand | 501-502 | 2 | 23 |
| β-strand | 506-510 | 5 | 22 |
| β-strand | 523-526 | 4 | 22 |
| β-strand | 530-533 | 4 | 22 |
| β-strand | 538-541 | 4 | 22 |
| β-strand | 543-544 | 2 | 23 |
| β-strand | 549-552 | 4 | 22 |
| β-strand | 563-566 | 4 | 22 |
| β-strand | 577 | 1 | 21 |
| α-helix | 578-580 | 3 | |
| β-strand | 588-594 | 7 | 24 |
| α-helix | 597-599 | 3 | |
| α-helix | 600-613 | 14 | |
| β-strand | 618-621 | 4 | 24 |
| β-strand | 627-631 | 5 | 24 |
| α-helix | 634-643 | 10 | |
| α-helix | 644-648 | 5 | |
| β-strand | 653-655 | 3 | 24 |
| α-helix | 656-658 | 3 | |
| β-strand | 659-660 | 2 | 24 |
| β-strand | 663-666 | 4 | 25 |
| β-strand | 674-677 | 4 | 26 |
| β-strand | 684-691 | 8 | 26 |
| α-helix | 692-693 | 2 | |
| α-helix | 696-701 | 6 | |
| α-helix | 711-722 | 12 | |
| α-helix | 726-729 | 4 | |
| β-strand | 732-734 | 3 | 26 |
| β-strand | 744-747 | 4 | 26 |
| α-helix | 756-776 | 21 | |
| β-strand | 783-784 | 2 | 25 |
| β-strand | 787-795 | 9 | 26 |
| α-helix | 808-822 | 15 | |
| β-strand | 825-839 | 15 | 25 |
| α-helix | 843-851 | 9 | |
| β-strand | 856-862 | 7 | 25 |
| β-strand | 868-876 | 9 | 25 |
| α-helix | 878-880 | 3 | |
| α-helix | 883-890 | 8 | |
| β-strand | 896-906 | 11 | 25 |
| α-helix | 923-925 | 3 | |
| α-helix | 926-928 | 3 | |
| α-helix | 929-941 | 13 | |
Chain D: 6 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 244-254 | 11 | |
| α-helix | 276-277 | 2 | |
| α-helix | 278-280 | 3 | |
| α-helix | 288-290 | 3 | |
| α-helix | 293-296 | 4 | |
| α-helix | 298-300 | 3 | |
Chain E: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 96-113 | 18 | |
| α-helix | 117-126 | 10 | |
| α-helix | 138-149 | 12 | |
| α-helix | 154-156 | 3 | |
Chain F: 10 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 63-67 | 5 | |
| α-helix | 68-71 | 4 | |
| β-strand | 81 | 1 | 1 |
| β-strand | 86 | 1 | 1 |
| β-strand | 87 | 1 | 2 |
| α-helix | 93-98 | 6 | |
| β-strand | 101 | 1 | 3 |
| β-strand | 107 | 1 | 3 |
| α-helix | 118-121 | 4 | |
| α-helix | 151-153 | 3 | |
| α-helix | 154-163 | 10 | |
| β-strand | 170 | 1 | 4 |
| α-helix | 171-178 | 8 | |
| α-helix | 196-212 | 17 | |
| α-helix | 217-219 | 3 | |
| β-strand | 221 | 1 | 4 |
| α-helix | 222-232 | 11 | |
Chain h: 1 helix, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-10 | 4 | |
| β-strand | 16-21 | 6 | 28 |
| β-strand | 26-34 | 9 | 28 |
| β-strand | 40-49 | 10 | 28 |
| β-strand | 63-72 | 10 | 28 |
| β-strand | 77-84 | 8 | 28 |
Chain i: 2 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-8 | 6 | |
| β-strand | 13-19 | 7 | 28 |
| β-strand | 24-32 | 9 | 28 |
| β-strand | 38-46 | 9 | 28 |
| β-strand | 53-60 | 8 | 28 |
| β-strand | 65-70 | 6 | 28 |
| α-helix | 76-79 | 4 | |
5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| CD2 antigen cytoplasmic tail-binding protein 2 | F | protein | 341 | Homo sapiens | O95400 (AlphaFold model) |
| Pre-mRNA-processing-splicing factor 8 | A | protein | 2335 | Homo sapiens | Q6P2Q9 (AlphaFold model) |
| U5 snRNA | 5 | RNA | 117 | Homo sapiens | |
| Pre-mRNA-processing factor 6 | E | protein | 941 | Homo sapiens | O94906 (AlphaFold model) |
| Probable ATP-dependent RNA helicase DDX23 | D | protein | 820 | Homo sapiens | Q9BUQ8 (AlphaFold model) |
| 116 kDa U5 small nuclear ribonucleoprotein component | C | protein | 972 | Homo sapiens | Q15029 |
| U5 small nuclear ribonucleoprotein 200 kDa helicase | B | protein | 2136 | Homo sapiens | O75643 |
| Small nuclear ribonucleoprotein F | m | protein | 86 | Homo sapiens | P62306 |
| Small nuclear ribonucleoprotein G | n | protein | 76 | Homo sapiens | P62308 |
| Small nuclear ribonucleoprotein Sm D1 | i | protein | 119 | Homo sapiens | P62314 |
| Small nuclear ribonucleoprotein Sm D2 | j | protein | 118 | Homo sapiens | P62316 |
| Small nuclear ribonucleoprotein Sm D3 | k | protein | 126 | Homo sapiens | P62318 |
2 more molecules are not listed.
Sequence of entity 1 (F), FASTA
>8Q91_1 CD2 antigen cytoplasmic tail-binding protein 2 (chains F)
MPKRKVTFQGVGDEEDEDEIIVPKKKLVDPVAGSGGPGSRFKGKHSLDSDEEEDDDDGGS
SKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNRDAQIRDSWL
DNIDWVKIRERPPGQRQASDSEEEDSLGQTSMSAQALLEGLLELLLPRETVAGALRRLGA
RGGGKGRKGPGQPSSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCQTLGPH
NPTPPPSLDMFAEELAEEELETPTPTQRGEAESRGDGLVDVMWEYKWENTGDAELYGPFT
SAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT
Sequence of entity 2 (A), FASTA
>8Q91_2 Pre-mRNA-processing-splicing factor 8 (chains A)
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKED
MPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLY
HITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYR
LANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDIN
KIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRR
ALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATK
FFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMR
QIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQF
EGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCW
KANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLT
RLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLI
LALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMD
LYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGIN
NLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYK
DMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATE
AAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARM
RLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKC
RTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIV
NKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPK
ELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFI
DSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRT
DFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEG
LFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGI
FMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSY
KMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYA
RAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPAL
YVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTT
KPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQ
IIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLY
DDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVE
VQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLT
ATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKET
GYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLP
GQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTP
GSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWN
YNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA
Sequence of entity 3 (5), FASTA
>8Q91_3 U5 snRNA (chains 5)
AUACUCUGGUUUCUCUUCAGAUCGCAUAAAUCUUUCGCCUUUUACUAAAGAUUUCCGUGG
AGAGGAACAACUCUGAGUCUUAACCCAAUUUUUUGAGGCCUUGCUUUGGCAAGGCUA
Sequence of entity 4 (E), FASTA
>8Q91_4 Pre-mRNA-processing factor 6 (chains E)
MNKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQM
KKNQAADDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERR
EQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNKRQRNPRYEKLT
PVPDSFFAKHLQTGENHTSVDPRQTQFGGLNTPYPGGLNTPYPGGMTPGLMTPGTGELDM
RKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKS
VRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKA
VVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEEPEDAR
IMLSRAVECCPTSVELWLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNT
QMVEKIIDRAITSLRANGVEINREQWIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRK
HTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRA
VAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYER
ARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEE
QKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLW
LESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKCEHD
PHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKR
CESAEPRHGELWCAVSKDIANWQKKIGDILRLVAGRIKNTF
Sequence of entity 5 (D), FASTA
>8Q91_5 Probable ATP-dependent RNA helicase DDX23 (chains D)
MAGELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSR
SRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRK
DRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQE
VEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREE
KDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLG
RGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQK
KLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQ
AIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTREL
AQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVL
SRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYR
QTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILE
QGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVA
TDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELK
QAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA
Sequence of entity 6 (C), FASTA
>8Q91_6 116 kDa U5 small nuclear ribonucleoprotein component (chains C)
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLH
EDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLA
DLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTE
RLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLIL
SPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKA
PTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVC
KKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTK
MYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIE
VNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSEL
PKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVV
TFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQT
KYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLC
DELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPA
DCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSV
FHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLE
LAKQDVVLNYPM
Sequence of entity 7 (B), FASTA
>8Q91_7 U5 small nuclear ribonucleoprotein 200 kDa helicase (chains B)
MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTK
PQMQEERRAKRRKRDEDRHDINKMKGYTLLSEGIDEMVGIIYKPKTKETRETYEVLLSFI
QAALGDQPRDILCGAADEVLAVLKNEKLRDKERRKEIDLLLGQTDDTRYHVLVNLGKKIT
DYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYGEVREEASDDDMEGDEAVVRCTL
SANLVASGELMSSKKKDLHPRDIDAFWLQRQLSRFYDDAIVSQKKADEVLEILKTASDDR
ECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLLASAQSEAEKERIMGKMEADPELSKFL
YQLHETEKEDLIREERSRRERVRQSRMDTDLETMDLDQGGEALAPRQVLDLEDLVFTQGS
HFMANKRCQLPDGSFRRQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKT
LNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIY
IAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKG
GERTYTQLVRLIILDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYED
VATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQ
VLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPY
GFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGR
WTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDM
LNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTA
ALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSL
SSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMAD
MVYVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVV
KKIEKKNFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKV
ELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFE
PLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESL
YQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVYIT
PMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWK
QRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDV
AHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSPKKPVI
VFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYL
HEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVDYP
IYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEI
VTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSK
CISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPI
RHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAI
RLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHIKRCTDKGVE
SVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQ
LEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATG
AHNYTLYFMSDAYMGCDQEYKFSVDVKEAETDSDSD
Sequence of entity 8 (m), FASTA
>8Q91_8 Small nuclear ribonucleoprotein F (chains m)
MSLPLNPKPFLNGLTGKPVMVKLKWGMEYKGYLVSVDGYMNMQLANTEEYIDGALSGHLG
EVLIRCNNVLYIRGVEEEEEDGEMRE
Sequence of entity 9 (n), FASTA
>8Q91_9 Small nuclear ribonucleoprotein G (chains n)
MSKAHPPELKKFMDKKLSLKLNGGRHVQGILRGFDPFMNLVIDECVEMATSGQQNNIGMV
VIRGNSIIMLEALERV
Sequence of entity 10 (i), FASTA
>8Q91_10 Small nuclear ribonucleoprotein Sm D1 (chains i)
MKLVRFLMKLSHETVTIELKNGTQVHGTITGVDVSMNTHLKAVKMTLKNREPVQLETLSI
RGNNIRYFILPDSLPLDTLLVDVEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR
Sequence of entity 11 (j), FASTA
>8Q91_11 Small nuclear ribonucleoprotein Sm D2 (chains j)
MSLLNKPKSEMTPEELQKREEEEFNTGPLSVLTQSVKNNTQVLINCRNNKKLLGRVKAFD
RHCNMVLENVKEMWTEVPKSGKGKKKSKPVNKDRYISKMFLRGDSVIVVLRNPLIAGK
Sequence of entity 12 (k), FASTA
>8Q91_12 Small nuclear ribonucleoprotein Sm D3 (chains k)
MSIGVPIKVLHEAEGHIVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQ
VYIRGSKIRFLILPDMLKNAPMLKSMKNKNQGSGAGRGKAAILKAQVAARGRGRGMGRGN
IFQKRR
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 1 |
Primary citation
Structure of the human 20S U5 snRNP. Schneider, S., Brandina, I., Peter, D. et al. Nat Struct Mol Biol (2024) 31:752-756. DOI 10.1038/s41594-024-01250-5 · PubMed
Other PDB entries of the same protein (UniProt O95400 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 1SYX 2.35 Å, The crystal structure of a binary U5 snRNP complex
- 4BWS 2.5 Å, Crystal structure of the heterotrimer of PQBP1, U5-15kD and U5-52kD.
- 8Q7Q 3.2 Å, Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 2)
- 8RC0 3.2 Å, Structure of the human 20S U5 snRNP
- 8Q7V 3.8 Å, Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1)
- 8Q7W 3.9 Å, Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 3)
- 8Q7X 4.6 Å, Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 4)
- 1GYF Gyf domain from human CD2BP2 protein
- 1L2Z CD2BP2-GYF domain in complex with proline-rich CD2 tail segment peptide
Browse structure collections
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