Splicing factor 1 (SF1) is a 639-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15637.
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The mean pLDDT of this model is 64.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 14% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 28% |
| Below 50 | Very low: often disordered regions | 32% |
What pLDDT means and how to read it
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor
Binds U2AF2. Interacts with U1 snRNA. Binds EWSR1, FUS and TAF15. Interacts with RBM17
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4FXW | X-ray | 2.29 Å | B/D=14-132 |
| 4FXX | X-ray | 2.48 Å | A/B/C/D=26-132 |
| 7VPX | EM | 3.0 Å | D=1-639 |
| 1K1G | NMR | A=133-260 | |
| 1O0P | NMR | B=13-25 | |
| 1OPI | NMR | B=13-25 | |
| 2M09 | NMR | A=27-145 | |
| 2M0G | NMR | A=1-145 | |
| 7VH9 | NMR | A=295-327 | |
| 8PXX | NMR | B=575-590 |
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