BRO1 domain-containing protein BROX (BROX) is a 411-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5VW32.
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The mean pLDDT of this model is 92.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 84% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Nuclear envelope-associated factor that is involved in the nuclear envelope ruptures during interphase (NERDI) repair, where it is locally recruited by CHMP5 and reduces cytoskeletal stress through its action on SYN2 to help reseal the ruptured membrane
Monomer (PubMed:22162750). Interacts with CHMP4B (PubMed:18190528, PubMed:22162750, PubMed:22484091, PubMed:34818527). Interacts with CHMP5: this interaction allows the recruitment of BROX to cellular membranes (PubMed:22484091). Interacts with SYN2; this interaction promotes SYN2 ubiquitination and facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the…
Nucleus membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3R9M | X-ray | 1.95 Å | A=2-374 |
| 3ZXP | X-ray | 2.5 Å | A/B/C=1-401 |
| 3UM2 | X-ray | 2.59 Å | A/D=2-377 |
| 3ULY | X-ray | 2.6 Å | A=2-411 |
| 3UM1 | X-ray | 2.71 Å | A/D=2-377 |
| 3UM0 | X-ray | 3.1 Å | A=2-411 |
| 3UM3 | X-ray | 3.8 Å | A=2-411 |
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