Multifunctional virulence effector protein DrrA (drrA) is a 647-residue protein from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5ZSQ3.
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The mean pLDDT of this model is 92.7 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 85% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Virulence effector that plays a key role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a GDP-GTP exchange factor (GEF) for the small GTPase Rab1 (RAB1A, RAB1B or RAB1C), thereby converting Rab1 to an active GTP-bound state, leading to the incorporation of Rab1 into LCVs. Also shows RabGDI displacement factor (GDF) activity; however, this probably represents a passive activity following the GEF activity. Also acts as an adenylyltransferase by mediating the addition of adenosine 5'-monophosphate (AMP) to 'Tyr-77' of host RAB1B, thereby rendering RAB1B…
Interacts with host RAB1A
Secreted, Host cytoplasmic vesicle membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2WWX | X-ray | 1.5 Å | B=317-533 |
| 3JZ9 | X-ray | 1.8 Å | A=340-533 |
| 3JZA | X-ray | 1.8 Å | B=340-533 |
| 4MXP | X-ray | 1.83 Å | A=330-647 |
| 3N6O | X-ray | 2.5 Å | A/B=340-647 |
| 3L0I | X-ray | 2.85 Å | A/C=193-550 |
| 3L0M | X-ray | 3.45 Å | A/B=317-647 |
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