Catenin alpha-2 (Ctnna2) is a 953-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q61301.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 80.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (PubMed:12123610, PubMed:15034585). Required for proper regulation of cortical neuronal migration and neurite growth. It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability (By similarity). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (PubMed:12089526)
Interacts with CDH1 and CDH2 (By similarity). Interacts with ZNF639; recruits CTNNA2 to the nucleus (By similarity). Interacts with F-actin (By similarity)
Cell membrane, Cytoplasm, Cytoplasm, cytoskeleton, Cell junction, adherens junction, Cell projection, axon, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5XFL | X-ray | 2.45 Å | A/B/C/D=260-632 |
| 4P9T | X-ray | 2.5 Å | A/B/C/D=13-261 |
| 4K1O | X-ray | 2.6 Å | A=651-953 |
| 4ONS | X-ray | 2.8 Å | A/C=18-264 |
| 6DUY | X-ray | 2.81 Å | A/B=651-953 |
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