Shieldin complex subunit 3 (SHLD3) is a 250-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6ZNX1.
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The mean pLDDT of this model is 78.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres
Component of the shieldin complex, consisting of SHLD1, SHLD2, SHLD3 and MAD2L2/REV7. Within the complex, SHLD2 forms a scaffold which interacts with a SHLD3-MAD2L2 subcomplex via its N-terminus, and with SHLD1 via its C-terminus (PubMed:29656893). Interacts with ASTE1 (PubMed:34354233)
Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6M7B | X-ray | 1.77 Å | C/D=37-73 |
| 6M7A | X-ray | 1.9 Å | C/D=28-73 |
| 6VE5 | X-ray | 2.0 Å | B=41-74 |
| 6K07 | X-ray | 2.24 Å | B=46-74 |
| 6K08 | X-ray | 2.31 Å | B=46-74 |
| 6WW9 | X-ray | 2.7 Å | X/Y=35-58 |
| 6KTO | X-ray | 3.45 Å | C=1-64 |
| 7L9P | EM | 3.6 Å | X/Y=2-58 |
| 6WWA | X-ray | 3.8 Å | X/Y=2-58 |
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