F-box only protein 22 (FBXO22) is a 403-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8NEZ5.
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The mean pLDDT of this model is 86.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 65% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that is implicated in the control of various cellular processes such as cell cycle control, transcriptional regulation, DNA damage repair, and apoptosis. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Acts as a key regulator of histone methylation marks namely H3K9 and H3K36 methylation through the regulation of histone demethylase KDM4A protein levels (PubMed:21768309). In complex with KDM4A, also regulates the abundance of TP53 by targeting methylated…
Directly interacts with SKP1 and CUL1 (PubMed:21768309, PubMed:22972877). Interacts (via C-terminal) with KDM4A (PubMed:21768309). Interacts with TP53 (PubMed:26868148). Interacts with MTOR; this interaction promotes 'lys-27'-linked ubiquitination of MTOR (PubMed:37979583)
Cytoplasm, Nucleus, Cytoplasm, myofibril, sarcomere, Z line
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8S7D | EM | 3.2 Å | D=12-403 |
| 8S7E | EM | 3.4 Å | B=12-403 |
| 8UA3 | EM | 3.8 Å | C=1-403 |
| 8UA6 | EM | 3.9 Å | C=1-403 |
| 29HG | EM | 4.0 Å | A=1-403 |
| 29HH | EM | 4.2 Å | A=1-403 |
| 29HI | EM | 5.9 Å | A=1-403 |
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