[F-actin]-monooxygenase MICAL1 (MICAL1) is a 1067-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8TDZ2.
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The mean pLDDT of this model is 74.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:29343822). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023, PubMed:29343822). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the…
Interacts with STK38 and STK38L (By similarity). Interacts with RAB1B, RAB8A, RAB10, RAB13, RAB15 and RAB35 (in their GTP-bound forms); binding to RAB1B is of low affinity compared to other Rab proteins; at least in case of RAB8A and RAB10 can bind 2 molecules of the Rab proteins simultaneously; ternary complex formation of RAB8A, RAB13 and MICAL1 is possible. Associates with the SH3 domain of…
Cytoplasm, Cytoplasm, cytoskeleton, Endosome membrane, Midbody
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8HLO | X-ray | 1.17 Å | C=828-836 |
| 6KU0 | X-ray | 1.6 Å | B/D=799-822 |
| 9G0C | X-ray | 1.8 Å | A=918-1067 |
| 9G0D | X-ray | 2.05 Å | B=918-1067 |
| 5LPN | X-ray | 2.8 Å | B=918-1067 |
| 9EWY | EM | 3.1 Å | A=1-1067 |
| 5LE0 | X-ray | 3.3 Å | B=918-1067 |
| 8Y6K | EM | 3.94 Å | A=1-1067 |
| 1WYL | NMR | A=510-612 | |
| 2CO8 | NMR | A=687-755 | |
| 2DK9 | NMR | A=506-614 |
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