G-protein-signaling modulator 2 (Gpsm2) is a 679-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8VDU0.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 67.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 44% |
What pLDDT means and how to read it
Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Plays a role in metaphase spindle orientation (By similarity). Plays an important role in asymmetric cell divisions (PubMed:12571286, PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (PubMed:22952234)
Interacts with the dynein-dynactin complex; this interaction is inhibited in a PLK1-dependent manner (By similarity). Part of a spindle orientation complex at least composed of GNAI1, GPSM2 and NUMA1 (By similarity). Interacts with LLGL2 (By similarity). Interacts (via TPR repeat region) with INSC/inscuteable (PubMed:16094321, PubMed:21816348). Interacts (via TPR repeat region) with NUMA1 (via…
Cytoplasm, Cytoplasm, cell cortex, Cytoplasm, cytoskeleton, spindle pole, Lateral cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3RO3 | X-ray | 1.1 Å | A=198-357 |
| 3RO2 | X-ray | 2.3 Å | A=22-357 |
| 4G2V | X-ray | 2.4 Å | A=22-357 |
| 7EP7 | X-ray | 2.6 Å | A=22-357 |
| 4JHR | X-ray | 2.8 Å | A/B=96-357, A/B=593-651 |
| 4G5O | X-ray | 2.9 Å | E/F/G/H=628-653 |
| 4G5Q | X-ray | 2.9 Å | E/F/G/H=628-652 |
| 4G5R | X-ray | 3.48 Å | E/F/G/Z=628-652 |
| 4G5S | X-ray | 3.62 Å | E/F/G/Z=594-618 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.