Cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1) is a 329-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8WTX7.
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The mean pLDDT of this model is 88.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 76% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:26972053, PubMed:27487210, PubMed:33594058). As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1 (PubMed:26972053, PubMed:27487210, PubMed:33594058). Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway (PubMed:26972053, PubMed:27487210, PubMed:33594058)
Forms homodimers and heterodimers with CASTOR2 (PubMed:26972053, PubMed:27487210). Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by arginine (PubMed:26972053, PubMed:27487210, PubMed:33594058). Interacts with TM4SF5; the interaction is positively regulated by leucine and is negatively regulated by arginine…
Cytoplasm, cytosol
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5I2C | X-ray | 1.8 Å | A/B/C/D=1-329 |
| 5GT7 | X-ray | 2.05 Å | A/B/C/D=1-323 |
| 5GV2 | X-ray | 2.06 Å | A/C=1-329 |
| 5GS9 | X-ray | 2.5 Å | A/B/C/D=1-329 |
| 5GT8 | X-ray | 2.8 Å | A/B/C/D=1-329 |
| 9KP4 | X-ray | 3.08 Å | A/B/C/D=1-329 |
| 9LWF | EM | 3.41 Å | U/V=1-329 |
| 9OTI | EM | 3.5 Å | U/V=1-329 |
| 9LVK | EM | 3.59 Å | U/V=1-329 |
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