U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) is a 499-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8WWY3.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 77.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 41% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:20118938, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543)
Identified in the spliceosome B complex (PubMed:28781166). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39 (PubMed:11867543, PubMed:16723661, PubMed:26912367). Interacts with a complex formed by SNU13 and U4 snRNA, but not with SNU13 or…
Nucleus, Nucleus speckle, Nucleus, Cajal body
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2OZB | X-ray | 2.6 Å | B/E=78-333 |
| 8H6L | EM | 2.6 Å | 4D=1-499 |
| 3SIU | X-ray | 2.63 Å | B/E=85-333 |
| 8H6K | EM | 2.7 Å | 4D=1-499 |
| 6QW6 | EM | 2.92 Å | 4C=1-499 |
| 8Q7N | EM | 3.1 Å | L=1-499 |
| 8QOZ | EM | 3.1 Å | L=1-499 |
| 8QPE | EM | 3.1 Å | L=1-499 |
| 8H6E | EM | 3.2 Å | 4D=1-499 |
| 8H6J | EM | 3.25 Å | 4D=1-499 |
| 6QX9 | EM | 3.28 Å | 4C=1-499 |
| 3SIV | X-ray | 3.3 Å | B/E/H/K=85-333 |
| 8Y6O | EM | 3.38 Å | L=1-499 |
| 8QP8 | EM | 3.5 Å | L=1-499 |
| 8QPA | EM | 3.7 Å | L=1-499 |
| 8QPB | EM | 3.7 Å | L=1-499 |
| 6AHD | EM | 3.8 Å | L=1-499 |
| 8QP9 | EM | 4.1 Å | L=1-499 |
| 8QZS | EM | 4.1 Å | L=1-499 |
| 8QPK | EM | 4.2 Å | L=1-499 |
Showing 20 of 30 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.